Related Experiment Video

Updated: Nov 20, 2025

Antimicrobial Synergy Testing by the Inkjet Printer-assisted Automated Checkerboard Array and the Manual Time-kill Method
12:03

Antimicrobial Synergy Testing by the Inkjet Printer-assisted Automated Checkerboard Array and the Manual Time-kill Method

Published on: April 18, 2019

26.9K

Antibiotics in treatment of peritonsillar infection: clindamycin versus penicillin

F Hallgren1, E Lindell1, B Nilsson-Helger1

  • 1Department of Otorhinolaryngology Head and Neck Surgery, Södra Älvsborg Hospital, Borås, Institute of Clinical Sciences, Sahlgrenska Academy, Gothenburg University, Sweden.

The Journal of Laryngology and Otology
|January 22, 2021
PubMed
Abstract

Insights

Penicillin and clindamycin show similar recovery and recurrence rates for peritonsillar infections. Penicillin is recommended as a first-line treatment due to clindamycin

Area of Science:

  • Otolaryngology
  • Infectious Diseases
  • Pharmacology

Background:

  • Peritonsillar infections, including cellulitis and abscess, are common. Antibiotic choice impacts patient outcomes and microbial resistance.
  • Clindamycin and penicillin are frequently used, but direct comparisons of their efficacy and recurrence rates are limited.

Purpose of the Study:

  • To compare the efficacy of clindamycin versus penicillin V or G in treating peritonsillar infections.
  • To evaluate differences in time to recovery and recurrence rates between the two antibiotic groups.

Main Methods:

  • Retrospective cohort study of 296 patients with peritonsillar infection.
  • Patients were categorized into clindamycin or penicillin groups based on prescribed antibiotic.
  • Follow-up data on recovery and recurrence within two months were analyzed.

Main Results:

  • Mean follow-up duration was similar: 3.5 days for clindamycin and 3.4 days for penicillin.
  • Recurrence rates within two months were 7% for clindamycin and 4% for penicillin.
  • No statistically significant difference in recovery or recurrence was observed between the groups.

Conclusions:

  • Both clindamycin and penicillin are effective for peritonsillar infections, with comparable recovery and recurrence rates.
  • Penicillin is supported as a first-line agent due to clindamycin's potential for adverse effects and impact on gut microbiota.
  • Further research may explore long-term outcomes and resistance patterns associated with each antibiotic.
Keywords:
Anti-Bacterial AgentsClindamycinPenicillinsPeritonsillar Abscess

More Related Videos

A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii09:17

A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii

Published on: January 2, 2017

14.9K
A Platform of Anti-biofilm Assays Suited to the Exploration of Natural Compound Libraries09:39

A Platform of Anti-biofilm Assays Suited to the Exploration of Natural Compound Libraries

Published on: December 27, 2016

18.2K

Related Concept Videos

Tonsillitis II: Management01:26

Tonsillitis II: Management

This lesson will focus on the different treatment options for managing tonsillitis, which typically depend on the cause and severity.
261
Acute Pharyngitis01:30

Acute Pharyngitis

Introduction
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
2.6K
Tonsillitis I: Introduction01:30

Tonsillitis I: Introduction

Tonsillitis is inflammation of the tonsils, which are two lymphoid tissue masses at the back of the throat. This condition can cause discomfort and irritation in the throat.
Etiology
Three primary contributing factors have been identified.
1.0K
Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
140
Chronic Pharyngitis01:23

Chronic Pharyngitis

Chronic pharyngitis refers to persistent inflammation of the pharyngial mucosa.
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
8.2K
Pneumonia IV: Management01:28

Pneumonia IV: Management

The treatment of pneumonia varies based on its severity and the causative pathogen. Here is a structured approach to managing pneumonia, integrating pharmaceutical and supportive care strategies.
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
583