Congenital toxoplasmosis in an infant with hydrops fetalis

We have described an infant born with severe hydrops fetalis due to congenital toxoplasmosis. Although uncommon, toxoplasmosis should be considered in the differential diagnosis of hydrops fetalis, particularly when the preliminary clinical work-up suggests a nonimmunologic basis for the hydrops. Although the clinical outcome in an infant as severely affected as this one will remain poor, the therapy for toxoplasmosis has improved over the years, and with quick diagnosis of the disease, a less severely affected infant may have a better prognosis.