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Immunohistochemical Analysis of Programmed Death-Ligand 1 Expression in Equine Sarcoids
Jennifer Benvegnen1, Bettina De Breuyn2, Vinzenz Gerber3
1Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, Bern, Switzerland; Swiss Institute of Equine Medicine (ISME), Department of Clinical Veterinary Medicine, Vetsuisse Faculty, University of Bern and Agroscope, Bern, Switzerland.
Abstract:
The aim of the study was to assess the expression of the immune checkpoint inhibitor programmed death-ligand 1 (PD-L1) in equine sarcoids (ES). Programmed death-ligand 1 is expressed by various cancer cells to block T cell-mediated elimination of tumor cells. Antibodies targeting human PD-L1 were tested by immunohistochemistry for their cross-reactivity with equine PD-L1 using formalin-fixed, paraffin-embedded tissues. Our results do not support an important role of PD-L1-mediated immune evasion in ES disease and hence do not offer a rationale for anti-PD-1/PD-L1-based immunotherapy against ES.
