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Quantitative Fundus Autofluorescence for the Evaluation of Retinal Diseases
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Correlation between fundus autofluorescence and visual function in patients with cone-rod dystrophy.

Satoru Kanda1,2, Takumi Hara2, Ryosuke Fujino1,2

  • 1Asahi General Hospital, 1326, Asahi-shi, Chiba, Japan.

Scientific Reports
|January 22, 2021
PubMed
Summary

Autofluorescence (AF) measurements in cone-rod dystrophy (CORD) patients reveal that the low AF area ratio (LFAR) reflects visual field deterioration. However, AF measurements do not correlate with visual acuity (VA) in CORD.

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Area of Science:

  • Ophthalmology
  • Retinal Imaging
  • Genetic Eye Diseases

Background:

  • Cone-rod dystrophy (CORD) is a group of inherited retinal diseases.
  • Visual function assessment in CORD is crucial for monitoring disease progression.
  • Ultra-wide field imaging offers a comprehensive view of retinal changes.

Purpose of the Study:

  • To investigate the relationship between autofluorescence (AF) signals and visual functions in CORD patients.
  • To determine if AF measurements can predict visual field loss or visual acuity decline.
  • To explore the utility of low autofluorescence area ratio (LFAR) in CORD.

Main Methods:

  • Retrospective chart review of 21 CORD patients (37 eyes).
  • Simultaneous visual field testing, fundus autofluorescence (FAF) measurement, and optical coherence tomography (OCT).
  • Analysis of binarised FAF images to calculate LFAR (low FAF/30°).

Main Results:

  • A significant relationship was found between logMAR visual acuity (VA) and mean deviation (MD) (p=0.001).
  • LogMAR VA correlated significantly with central retinal thickness (CRT) (p=0.006).
  • Multivariate analysis showed LFAR was significantly associated with MD (p=0.002), indicating visual field deterioration.

Conclusions:

  • Low autofluorescence area ratio (LFAR) measurement is a useful tool in managing CORD patients.
  • AF measurements, specifically LFAR, reflect visual field deterioration in CORD.
  • AF measurements do not appear to reflect visual acuity in CORD patients.