Related Experiment Video

Updated: Nov 20, 2025

Author Spotlight: Exploring the Impact of Reduced Resistance Exercise Volume on Metabolic Health
06:13

Author Spotlight: Exploring the Impact of Reduced Resistance Exercise Volume on Metabolic Health

Published on: December 1, 2023

1.4K

Association between triglyceride glucose index and peak growth hormone in children with short stature

Qianqian Zhao1,2,3, Yuntian Chu4, Hui Pan5,3

  • 1Department of Endocrinology, Qingdao University, Qingdao, 266071, Shandong, People's Republic of China.

Scientific Reports
|January 22, 2021
PubMed

Insights

The triglyceride (TyG) index may indicate growth hormone (GH) deficiency in children with short stature. A higher TyG index, particularly above 7.8, is linked to lower peak GH levels, suggesting a potential diagnostic marker.

Area of Science:

  • Pediatric Endocrinology
  • Metabolic Syndrome Research

Background:

  • Growth hormone (GH) secretion is influenced by various factors and GH provocation tests show poor reproducibility.
  • Identifying reliable indicators for GH deficiency (GHD) in children with short stature is crucial for accurate diagnosis and timely intervention.

Purpose of the Study:

  • To investigate the association between the triglyceride (TyG) index and peak GH levels in children presenting with short stature.
  • To determine if the TyG index can serve as a predictive marker for GH deficiency in pediatric populations.

Main Methods:

  • A cohort of 1095 children with short stature were analyzed, categorized into GH deficiency (GHD) and non-GHD groups based on GH provocation tests.
  • Statistical analyses were performed to assess the relationship between the TyG index and peak GH levels, including nonlinear association testing.

Main Results:

  • Children in the GHD group exhibited significantly higher TyG index values compared to the non-GHD group (P < 0.001).
  • A nonlinear relationship was identified between the TyG index and peak GH, with a critical threshold at 7.8.
  • A significant negative association was found between the TyG index and peak GH when the index exceeded 7.8 (β = -2.61, P < 0.001).

Conclusions:

  • The triglyceride (TyG) index demonstrates a nonlinear relationship with peak GH levels in children with short stature.
  • An elevated TyG index, especially above 7.8, is associated with reduced peak GH, suggesting its potential utility in evaluating pediatric short stature and possible GH deficiency.

More Related Videos

Comparative Analysis of Human Growth Hormone in Serum Using SPRi, Nano-SPRi and ELISA Assays11:17

Comparative Analysis of Human Growth Hormone in Serum Using SPRi, Nano-SPRi and ELISA Assays

Published on: January 7, 2016

16.9K
Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT08:13

Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT

Published on: January 7, 2018

70.4K

Related Concept Videos

Nature and Nurture01:10

Nature and Nurture

Many human characteristics, like height, are shaped by both nature—in other words, by our genes—and by nurture, or our environment. For example, chronic stress during childhood inhibits the production of growth hormones and consequently reduces bone growth and height. Scientists estimate that 70-90% of variation in height is due to genetic differences among individuals, and 10-30% of variation in height is due to differences in the environments that individuals experience,...
21.5K
Signs of Puberty01:27

Signs of Puberty

Puberty is a critical phase, typically beginning between the ages of 8 and 13 in girls and 9 and 14 in boys, though timing can vary based on genetics, environmental factors, and overall health. This period is characterized by the development of secondary sexual characteristics and the attainment of reproductive potential. Endocrine changes underpin puberty, with hormonal surges of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) instigated by Gonadotropin-Releasing Hormone (GnRH)...
924
Hypoglycemia and Glucagon01:15

Hypoglycemia and Glucagon

Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
549
Glucose Homeostasis: Regulation of Blood Glucose01:02

Glucose Homeostasis: Regulation of Blood Glucose

Carbohydrates consumed through foods are converted into glucose, a crucial energy source for the body. In the prandial state, high blood glucose levels stimulate the secretion of insulin from the pancreas. Insulin inhibits hepatic glucose production and stimulates glucose uptake and metabolism by muscle and adipose tissue. The excess glucose is converted into glycogen and stored in the liver and muscles.
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...
3.2K
Hormones Regulating Blood Glucose01:16

Hormones Regulating Blood Glucose

Insulin is released by beta cells of the pancreas when blood glucose levels are high. It facilitates glucose absorption and utilization in insulin-dependent cells with insulin receptors on their plasma membranes. Insulin promotes glucose uptake by increasing the number of glucose transport proteins in the cell membrane, allowing glucose to enter the cell. As a result, glucose utilization and ATP production are enhanced.
In addition to accelerating glucose uptake and utilization, insulin has...
5.7K
Polygenic Traits01:18

Polygenic Traits

When more than one gene is responsible for a given phenotype, the trait is considered polygenic. Human height is a polygenic trait. Studies have uncovered hundreds of loci that influence height, and there are believed to be many more. Due to the high number of genes involved, as well as environmental and nutritional factors, height varies significantly within a given population. The distribution of height forms a bell-shaped curve, with relatively few individuals in the population at the...
67.8K