Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Operon Model

Operon Model

The operon model represents a fundamental mechanism of gene regulation in prokaryotes, enabling coordinated expression of genes involved in related metabolic or functional pathways. Operons consist of structural genes, a promoter, and an operator, with transcription regulated by repressors, activators, and small effector molecules.Structure and Function of OperonsAn operon is a cluster of structural genes transcribed together under the control of a single promoter. The promoter region...

Short-distance Transport of Resources

Short-distance Transport of Resources

Short-distance transport refers to transport that occurs over a distance of just 2-3 cells, crossing the plasma membrane in the process. Small uncharged molecules, such as oxygen, carbon dioxide, and water, can diffuse across the plasma membrane on their own. In contrast, ions and larger molecules require the assistance of transport proteins due to their charge or size. Transport across membranes also occurs within individual cells, playing a variety of essential roles for the plant as a whole.

Energy Budgets

Energy Budgets

Organisms must balance energy intake with the energy required for growth, maintenance and reproduction. These trade-offs result in a variety of survivorship and reproductive strategies, including semelparity and iteroparity. Semelparous species, like annual plants, have only one reproductive episode in their lifetimes and consequently have short lifespans. Iteroparous species, by contrast, have many reproductive events during their lifetimes but have relatively few offspring. These two...

Ecological Niches

Ecological Niches

All organisms have a position within an ecosystem. The complete set of living and nonliving factors—including food resources, climate, and terrain—that define the position of a given organism are collectively referred to as the organism’s ecological niche.

Optimal Foraging

Optimal Foraging

How animals obtain and eat their food is called foraging behavior. Foraging can include searching for plants and hunting for prey and depends on the species and environment.

Metabolic Rate

Metabolic Rate

The human body is a powerhouse of energy, with every cell performing numerous functions that require energy. This energy production and consumption is measured by the metabolic rate, which quantifies the total heat generated by all the body's chemical reactions and mechanical work. This measurement helps to determine the rate of kilocalorie (kcal) consumption needed to fuel all ongoing activities.
The Basal Metabolic Rate (BMR) measures the energy expended at rest.
Several factors influence...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

High-purity stem cell-derived β-cells recapitulate key transcriptional and functional features of human islets.

bioRxiv : the preprint server for biology·2026

Same author

Clonal biases dictate availability of colonic cancer driver mutations for transformation.

Nature communications·2026

Same author

Dlk1 is a novel adrenocortical stem/progenitor cell marker that predicts malignancy in adrenocortical carcinoma.

Cancer communications (London, England)·2025

Same author

Haploinsufficient phenotypes promote selection of PTEN and ARID1A-deficient clones in human colon.

EMBO reports·2025

Same author

ccfDNA analysis for the classification of adrenocortical adenomas.

Journal of endocrinological investigation·2025

Same author

Cellular landscape of adrenocortical carcinoma at single-nuclei resolution.

Molecular and cellular endocrinology·2024

Search research articles

Related Experiment Video

Updated: Nov 20, 2025

Workflow Based on the Combination of Isotopic Tracer Experiments to Investigate Microbial Metabolism of Multiple Nutrient Sources

Workflow Based on the Combination of Isotopic Tracer Experiments to Investigate Microbial Metabolism of Multiple Nutrient Sources

Published on: January 22, 2018

Cooperative metabolic resource allocation in spatially-structured systems.

David S Tourigny¹

¹Columbia University Irving Medical Center, 630 West 168th Street, New York, NY, 10032, USA. dst2156@cumc.columbia.edu.

Journal of Mathematical Biology

|January 22, 2021

Summary

Cooperation in metabolic regulation benefits organisms by allowing individuals to adapt resource allocation based on community welfare. This dynamic strategy, using limited global information, optimizes population performance.

Keywords:

Elementary flux mode Flux balance analysis Information theory Maximum entropy Metabolism Optimal control Social welfare

More Related Videos

High-Throughput Metabolic Profiling for Model Refinements of Microalgae

High-Throughput Metabolic Profiling for Model Refinements of Microalgae

Published on: December 4, 2021

A Method for Measuring Metabolism in Sorted Subpopulations of Complex Cell Communities Using Stable Isotope Tracing

A Method for Measuring Metabolism in Sorted Subpopulations of Complex Cell Communities Using Stable Isotope Tracing

Published on: February 4, 2017

Related Experiment Videos

Last Updated: Nov 20, 2025

Workflow Based on the Combination of Isotopic Tracer Experiments to Investigate Microbial Metabolism of Multiple Nutrient Sources

Workflow Based on the Combination of Isotopic Tracer Experiments to Investigate Microbial Metabolism of Multiple Nutrient Sources

Published on: January 22, 2018

High-Throughput Metabolic Profiling for Model Refinements of Microalgae

High-Throughput Metabolic Profiling for Model Refinements of Microalgae

Published on: December 4, 2021

A Method for Measuring Metabolism in Sorted Subpopulations of Complex Cell Communities Using Stable Isotope Tracing

A Method for Measuring Metabolism in Sorted Subpopulations of Complex Cell Communities Using Stable Isotope Tracing

Published on: February 4, 2017

Area of Science:

Evolutionary biology
Systems biology
Metabolic regulation

Background:

Natural selection favors social cooperation over individualistic metabolic strategies in cells and multicellular organisms.
Existing frameworks for dynamic metabolic resource allocation use the maximum entropy principle for bet-hedging against environmental uncertainty.

Purpose of the Study:

To extend the maximum entropy principle framework to model spatiotemporal metabolism incorporating cooperation.
To explain how individuals can adapt metabolic resource allocation based on community welfare with limited global information.

Main Methods:

Developed a theoretical framework for dynamic metabolic resource allocation based on the maximum entropy principle.
Extended the framework to spatiotemporal models that include cooperative behaviors.
Incorporated an ensemble measure of total population performance as a form of global information.

Main Results:

The cooperative extension of the maximum entropy principle models how individuals adapt metabolic strategies based on limited knowledge of others' welfare.
Demonstrated that local regulation of metabolic cross-feeding can achieve community-wide metabolic objectives.
Showed that population performance, informed by quorum sensing or hormones, drives adaptive metabolic strategies.

Conclusions:

Cooperative metabolic regulation, guided by population performance, is an evolutionarily advantageous strategy.
The extended maximum entropy framework provides insights into the mechanisms of social cooperation in metabolic systems.
This theory bridges the gap between individual metabolic adaptation and community-level objectives.