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The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
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Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
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The Parathyroid Glands00:59

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The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
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Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
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Updated: Nov 20, 2025

Transoral Endoscopic Thyroidectomy Vestibular Approach for Thyroid Lobectomy
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Predictive factors for post-total thyroidectomy hypocalcaemia.

Chiraz Halwani, Senda Turki, Khémaies Akkari

    La Tunisie Medicale
    |January 22, 2021
    PubMed
    Summary
    This summary is machine-generated.

    Post-thyroidectomy hypocalcemia is a common complication. Key predictors include gradual mass onset, large nodules, low preoperative calcium, and thyroiditis, guiding preventive strategies for this thyroid surgery risk.

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    Area of Science:

    • Endocrinology
    • Surgical Oncology
    • Otolaryngology

    Background:

    • Post-thyroidectomy hypocalcemia is a frequent and serious complication of thyroid surgery.
    • Identifying predictive factors is crucial for targeted preventive treatment strategies.

    Purpose of the Study:

    • To identify predictive factors for hypocalcemia following total thyroidectomy.

    Main Methods:

    • Retrospective study of 260 patients undergoing total thyroidectomy over 5 years.
    • Statistical analysis, including univariate and multivariate approaches, to identify predictors of hypocalcemia.

    Main Results:

    • The incidence of postoperative hypocalcemia was 31.9%.
    • Predictive factors identified include gradual mass onset, thyroid nodule size > 4 cm, preoperative calcium < 2.25 mmol/L, and histological thyroiditis.
    • Definitive hypoparathyroidism occurred in 1.1% of cases.

    Conclusions:

    • Post-thyroidectomy hypocalcemia is associated with intrinsic thyroid factors, preoperative calcium levels, and parathyroid gland injury.
    • Prevention strategies should involve calcium supplementation for at-risk patients and careful management of parathyroid glands during surgery.