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Association between chronic kidney disease and COVID-19-related mortality in New York
Nihal E Mohamed1, Emma K T Benn2, Varuna Astha2
1Department of Urology, Icahn School of Medicine at Mount Sinai, 6th Floor, 1425, Madison Ave, New York, NY, 10029, USA.
Insights
Patients with chronic kidney disease (CKD) face higher mortality risks from COVID-19. This increased risk is linked to factors like older age, male gender, and hypertension, highlighting health disparities.
Area of Science:
- Nephrology
- Infectious Diseases
- Public Health
Background:
- Chronic kidney disease (CKD) is a growing global health concern.
- The COVID-19 pandemic has disproportionately affected individuals with underlying health conditions.
- Understanding the interplay between CKD and COVID-19 is crucial for patient outcomes.
Purpose of the Study:
- To evaluate the mortality risk associated with COVID-19 in patients diagnosed with CKD.
- To identify shared characteristics contributing to health disparities in CKD patient outcomes during the COVID-19 pandemic.
Main Methods:
- Retrospective analysis of a case series involving 7624 patients tested for COVID-19 at Mount Sinai Health System.
- Data extracted from patients presenting between March 28, 2020, and April 16, 2020.
- Logistic regression analysis to control for demographic, behavioral, and clinical covariates.
Main Results:
- Approximately 7.8% of COVID-19 patients had CKD on admission.
- CKD patients exhibited higher mortality rates (23.1% vs. 10.2%) compared to non-CKD patients.
- CKD, older age, male gender, and hypertension were independently associated with increased COVID-19 mortality.
Conclusions:
- CKD is a significant independent predictor of mortality in COVID-19 patients.
- Older age, male gender, and hypertension also emerged as key predictors of mortality.
- Further research is warranted to explore the long-term effects of COVID-19 on renal function.
Purpose:
To evaluate mortality risk of CKD patients infected with COVID-19, and assess shared characteristics associated with health disparities in CKD outcome.
Methods:
We extracted the data from a case series of 7624 patients presented at Mount Sinai Health System, in New York for testing between 3/28/2020 and 4/16/2020. De-identified patient data set is being produced by the Scientific Computing department and made available to the Mount Sinai research community at the following website: https://msdw.mountsinai.org/ .
Results:
Of 7624 COVID-19 patients, 7.8% (n = 597) had CKD on hospital admission, and 11.2% (n = 856) died of COVID-19 infection. CKD patients were older, more likely to have diabetes, hypertension, and chronic obstructive pulmonary disease (COPD), were current or former smokers, had a longer time to discharge, and had worse survival compared to non-CKD patients (p < 0.05). COVID-19 mortality rate was significantly higher in CKD patients (23.1% vs 10.2%) with a 1.51 greater odds of dying (95% CI: 1.19-1.90). Controlling for demographic, behavioral, and clinical covariates, the logistic regression analysis showed significant and consistent effects of CKD, older age, male gender, and hypertension with mortality (p < 0.05).
Conclusion:
CKD was a significant independent predictor of COVID-19 mortality, along with older age, male gender, and hypertension. Future research will investigate the effects of COVID-19 on long-term renal function.
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