Thawing of fresh-frozen plasma at 45 degrees C versus 37 degrees C. Comparison using satellite packs of the same donor units

Packs of fresh-frozen plasma (FFP) from the same donor units were thawed at 37 degrees C and at 45 degrees C in order to determine the suitability of the higher temperature for thawing FFP. Measurements of prothrombin time, activated partial thromboplastin time, fibrinogen concentration, and Factor VIII activity showed no significant differences between the temperatures. Thawing time at 45 degrees C was approximately half that at 37 degrees C. The protocol for manipulation and inspection of the FFP was an important determinant of the thawing time, but did not appear to affect coagulation. FFP can safely be thawed in a 45 degrees C water bath if it is removed before thawing is complete.