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Updated: Nov 20, 2025

MicroRNA-based Regulation of Picornavirus Tropism
Published on: February 6, 2017
To Degrade a MicroRNA, Destroy Its Argonaute Protein
Pei-Hsuan Wu1, Phillip D Zamore1
1Howard Hughes Medical Institute and RNA Therapeutics Institute, University of Massachusetts Medical School, 368 Plantation Street, Worcester, MA 01605, USA.
Abstract:
Han et al. (2020) and Shi et al. (2020) report that the E3 ubiquitin ligase ZSWIM8 senses when an RNA and an Argonaute protein-bound microRNA are extensively base paired and directs Argonaute destruction by the proteasome. The result is degradation of the microRNA.
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