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Will advanced cholangiocarcinoma become a targetable malignancy?

Yara Sarkis1, Amine Al Soueidy1, Hampig Raphael Kourie1

  • 1Hematology-Oncology Department, Faculty of Medicine, Saint Joseph University of Beirut, Lebanon.

Critical Reviews in Oncology/Hematology
|January 22, 2021
PubMed

Insights

Targeted therapies show promise for advanced cholangiocarcinoma and biliary tract cancers. This review highlights effective treatments and ongoing clinical trials for these rare, aggressive tumors.

Area of Science:

  • Oncology
  • Genetics
  • Pharmacology

Background:

  • Cholangiocarcinoma and biliary tract cancers are rare, aggressive malignancies.
  • These cancers exhibit a heterogeneous molecular and genetic profile.
  • Specific genetic aberrations like FGFR2 fusion and ErBb2 amplification are frequently observed.

Purpose of the Study:

  • To review the efficacy and benefits of targeted therapy in advanced cholangiocarcinoma.
  • To summarize current research findings on targeted treatments.
  • To highlight therapeutic strategies being investigated in clinical trials.

Main Methods:

  • Literature review of recent studies on targeted therapies for cholangiocarcinoma.
  • Analysis of genetic aberrations common in biliary tract cancers.
  • Examination of ongoing clinical trials for advanced cholangiocarcinoma treatment.

Main Results:

  • Several targeted drugs demonstrate potential efficacy in treating advanced cholangiocarcinoma.
  • FGFR2 fusions and ErBb2 amplifications are key targets for therapeutic intervention.
  • Ongoing clinical trials are exploring novel treatment strategies.

Conclusions:

  • Targeted therapy represents a promising avenue for advanced cholangiocarcinoma and biliary tract cancers.
  • Further investigation of existing and novel targeted drugs is warranted.
  • Clinical trials are crucial for advancing treatment options for these rare cancers.
Keywords:
“advanced biliary tract cancer”“advanced cholangiocarcinoma”“genetic aberrations”“targeted therapy”

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