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Takotsubo syndrome: Does "Diabetes Paradox" exist?
Keerat Rai Ahuja1, Salik Nazir2, Vardhmaan Jain1
1Heart and Vascular Institute, Cleveland Clinic Foundation, Cleveland, OH, USA.
Heart & Lung : the Journal of Critical Care
|January 22, 2021
Summary
Diabetes mellitus (DM) is less prevalent in takotsubo syndrome (TTS) patients. Complicated DM patients experienced lower in-hospital mortality, but further research on long-term outcomes is needed.
Area of Science:
- Cardiology
- Endocrinology
- Public Health
Background:
- Conflicting findings exist on diabetes mellitus (DM) prevalence and outcomes in takotsubo syndrome (TTS).
- Assessing DM's impact on TTS patient outcomes is crucial for clinical management.
Purpose of the Study:
- To determine the prevalence of DM in TTS patients.
- To evaluate the association between DM and in-hospital outcomes in TTS.
Main Methods:
- Utilized the Nationwide Inpatient Sample (NIS) database from 2009-2015.
- Employed propensity score matching (PSM) to compare outcomes between TTS patients with and without DM.
Main Results:
- DM prevalence was 19.3% in TTS patients versus 23.1% in non-TTS patients (p<0.01).
- No significant differences in in-hospital mortality, stroke, cardiogenic shock, or other adverse events were observed between TTS patients with and without DM.
- Patients with complicated DM showed significantly lower in-hospital mortality compared to those without DM or with uncomplicated DM.
Conclusions:
- DM prevalence is lower in TTS patients compared to the general population.
- Complicated diabetes is associated with reduced in-hospital mortality in TTS.
- Further investigation into the mid- and long-term outcomes of DM in TTS is warranted.
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