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An Experimental and Finite Element Protocol to Investigate the Transport of Neutral and Charged Solutes across Articular Cartilage
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Bi-component T2 mapping correlates with articular cartilage material properties.

Matthew M Grondin1, Fang Liu2, Michael F Vignos1

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|January 22, 2021
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Summary

The fraction of fast-relaxing water (FF) measured with Multi-Component Driven Equilibrium Single Shot Observation of T1 and T2 (mcDESPOT) can non-invasively estimate knee cartilage

Keywords:
CartilageDissipationMagnetic resonance imagingMaterial propertiesT2 mapping

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Area of Science:

  • Biomedical Engineering
  • Medical Imaging
  • Orthopedics

Background:

  • Non-invasive estimation of cartilage material properties is crucial for assessing joint health and developing personalized computational models.
  • Multi-Component Driven Equilibrium Single Shot Observation of T1 and T2 (mcDESPOT) bi-component T2 mapping shows promise in detecting knee cartilage degeneration.
  • Previous studies have not established correlations between mcDESPOT-derived T2 parameters and cartilage composition or mechanical properties.

Purpose of the Study:

  • To investigate the relationship between bi-component T2 parameters obtained via mcDESPOT at 3.0T and the biochemical and mechanical characteristics of human patellar cartilage.

Main Methods:

  • Ex-vivo human patellar cartilage specimens were imaged using mcDESPOT at 3.0T.
  • Cartilage samples underwent mechanical testing for linear modulus and energy dissipation.
  • Biochemical analysis determined proteoglycan and collagen content.
  • mcDESPOT-derived parameters (T2, T2F, T2S, FF) were correlated with mechanical and compositional data using linear regression.

Main Results:

  • The fraction of fast-relaxing water (FF) significantly correlated with energy dissipation and linear modulus (p < 0.05).
  • Single-component T2 relaxation time (T2) correlated with elastic modulus and energy dissipation across all tested frequencies (p ≤ 0.05).
  • FF showed a significant correlation with proteoglycan content (p = 0.04).

Conclusions:

  • mcDESPOT-derived FF shows potential for non-invasively assessing cartilage proteoglycan content.
  • mcDESPOT parameters, particularly FF and T2, may serve as biomarkers for cartilage mechanical properties like elastic modulus and energy dissipation.
  • This technique offers a promising avenue for quantitative, non-invasive evaluation of cartilage health in clinical settings.