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Gestation and COVID-19: clinical and microbiological observational study (Gesta-COVID19)

Anna Suy1, Itziar Garcia-Ruiz2, Melchor Carbonell1

  • 1Department of Obstetrics, Hospital Universitari Vall d'Hebron, Barcelona, Spain.

BMC Pregnancy and Childbirth
|January 23, 2021
PubMed

Insights

This study investigates Coronavirus Disease 2019 (COVID-19) effects on pregnancy. Researchers will analyze maternal and fetal outcomes, and SARS-CoV-2 behavior in pregnant women and newborns.

Area of Science:

  • Obstetrics and Gynecology
  • Infectious Diseases
  • Virology

Background:

  • Coronavirus Disease 2019 (COVID-19) is a global pandemic with unclear effects on pregnancy.
  • Conflicting evidence exists regarding SARS-CoV-2 impact on maternal and fetal health.
  • SARS-CoV-2 has been detected in various pregnancy-related biological samples.

Purpose of the Study:

  • To investigate the effects of COVID-19 on pregnancy outcomes.
  • To understand how pregnancy status influences the evolution of SARS-CoV-2 disease.
  • To assess the risk of vertical transmission and viral behavior in biological fluids.

Main Methods:

  • A descriptive, multicenter, longitudinal, observational study across eight Spanish tertiary care hospitals.
  • Inclusion of pregnant women with positive SARS-CoV-2 tests and their newborns.
  • Collection and analysis of various biological samples (placenta, amniotic fluid, breastmilk, etc.) for viral detection and transmission studies.
  • Follow-up of neonates for up to 6 months to determine neonatal transmission rates.

Main Results:

  • The study aims to collect data from 150 pregnant women and their infants.
  • Analysis will focus on maternal and fetal effects, viral presence in biological samples, and vertical transmission.
  • Longitudinal follow-up will provide insights into neonatal outcomes and transmission rates.

Conclusions:

  • Limited information exists on COVID-19's effects during pregnancy and postpartum.
  • This study will provide comprehensive data on SARS-CoV-2 behavior in a Spanish pregnant population.
  • Findings will elucidate the impact of COVID-19 on pregnancy and neonates.
Abstract

Keywords:
Amniotic fluidBreastmilkCOVID-19Cord bloodPlacentaPregnancySARS-CoV-2Vertical transmission

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