Related Experiment Video

Updated: Nov 20, 2025

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
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Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

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C3 glomerulonephritis along with light chain proximal tubulopathy without crystal deposits in multiple myeloma: a

Junhui Xu1, Xiaojuan Yu2, Suxia Wang3

  • 1Department of Hematology, Peking University First Hospital, No.8 Xi Shi Ku Street, Xi ChengDistrict, Beijing, 100034, China.

World Journal of Surgical Oncology
|January 23, 2021
PubMed

Insights

Multiple myeloma can cause C3 glomerulonephritis (C3GN). This case shows mild C3GN in a patient with high light chain levels, highlighting the need for early diagnosis and treatment.

Area of Science:

  • Nephrology
  • Hematology
  • Immunology

Background:

  • Multiple myeloma is associated with various kidney injuries.
  • C3 glomerulonephritis (C3GN) involves abnormal complement C3 deposition due to alternative pathway activation.
  • The link between C3GN and multiple myeloma is established, but mild C3GN with high light chain levels is less reported.

Observation:

  • A 55-year-old man with IgA-type multiple myeloma presented with proteinuria.
  • Renal biopsy revealed C3GN and light chain proximal tubulopathy.
  • Despite elevated lambda serum-free light chains, the patient exhibited mild renal injury.

Findings:

  • Treatment with chemotherapy (BD, PAD) and autologous stem cell transplantation led to a very good partial hematologic response.
  • The patient maintained stable renal function post-treatment.
  • Persistent high levels of light chains in multiple myeloma can lead to C3GN and renal impairment.

Implications:

  • This case highlights the importance of monitoring renal function in multiple myeloma patients, especially those with high light chain levels.
  • Early identification and aggressive treatment strategies are crucial for managing C3GN in multiple myeloma.
  • Understanding the interplay between light chains, complement activation, and kidney injury is key for improved patient prognosis.
Abstract

Keywords:
Autologous stem cell transplantationC3 glomerulonephritisLight Chain proximal tubulopathy without crystal depositsMultiple myeloma

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