Related Experiment Video
Updated: Nov 20, 2025

Self-assembling Morphologies Obtained from Helical Polycarbodiimide Copolymers and Their Triazole Derivatives
Published on: February 7, 2017
Negatively charged cyclodextrins: Synthesis and applications in chiral analysis-A review
1School of Chemical Engineering and Technology, Tianjin Engineering Research Center of Functional Fine Chemicals, Tianjin University, Tianjin 300072, China.
Abstract:
The negatively charged cyclodextrins (CDs) play an important role in chiral analysis due to the additional electrostatic effect beyond the host-guest inclusion, especially in enantioanalysis of positively charged and electrically neutral analytes. This review presents recent advances in application of anionic CDs for enantioanalysis during the past five years. Firstly, the synthesis approaches of random substitution and single isomers of anionic CDs are briefly discussed. The main part focuses on the chiral analysis using anionic CDs in various analytical techniques, including capillary electrophoresis, high-performance liquid chromatography, capillary electrochromatography, counter current chromatography, nuclear magnetic resonance, etc. Particular attention is given to the capillary electrophoresis application since charged CDs could be used as a carrier of enantiomers by virtue of their self-mobility and offer an easy adjustment of the enantiomer migration order. Finally, future opportunities are also discussed in the conclusion of this review.
Related Concept Videos
Chirality in Nature
Prochirality
Stereoisomerism of Cyclic Compounds
Ion-Exchange Chromatography
Chirality
Chiral objects exhibit a sense of handedness when they interact with another chiral object. For example, our left foot can only fit in the left shoe and not in the right shoe. Achiral objects — objects that have...
Molecules with Multiple Chiral Centers

