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Acyclovir in human breast milk.

L J Meyer1, P de Miranda, N Sheth

  • 1Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City.

American Journal of Obstetrics and Gynecology
|March 1, 1988
PubMed
Summary
This summary is machine-generated.

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This study measured acyclovir levels in breast milk and serum of a lactating woman. Results indicate a low potential dose for infants, with milk concentrations higher than serum.

Area of Science:

  • Pharmacology
  • Neonatal Medicine
  • Maternal Health

Background:

  • Acyclovir is an antiviral medication used to treat herpes infections.
  • Lactating women may require acyclovir treatment, raising questions about infant exposure via breast milk.

Observation:

  • A lactating woman receiving oral acyclovir for herpes zoster was monitored.
  • Serum and milk samples were collected daily to quantify acyclovir concentrations.

Findings:

  • Acyclovir concentrations in breast milk were, on average, 3.24 times higher than in maternal serum.
  • The elimination half-life of acyclovir in breast milk was determined to be 2.8 hours.

Implications:

  • The higher milk-to-serum ratio suggests a potentially low acyclovir dose transferred to nursing infants.

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  • Further research is warranted to fully assess the safety and dosing of acyclovir in breastfeeding infants.