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Related Experiment Videos

Platelet-activating factor-induced increases in glucose kinetics.

C H Lang1, C Dobrescu, D M Hargrove

  • 1Department of Physiology, Louisiana State University Medical Center, New Orleans 70112.

The American Journal of Physiology
|February 1, 1988
PubMed
Summary

Platelet-activating factor (PAF) administration in rats mimics endotoxemia by altering glucose metabolism. PAF increases glucose appearance and plasma glucose levels, effects mediated by adrenergic pathways.

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Area of Science:

  • Endocrinology
  • Metabolic Physiology
  • Pharmacology

Background:

  • Platelet-activating factor (PAF) is implicated in endotoxin's hemodynamic effects.
  • Endotoxemia significantly impacts whole-body glucose metabolism.

Purpose of the Study:

  • To investigate if PAF administration in vivo can replicate endotoxemia-like changes in glucose metabolism.
  • To assess the dose-dependent effects of PAF on glucose kinetics and hormonal responses.

Main Methods:

  • Glucose kinetics were measured in conscious rats using constant infusion of radiolabeled glucose ([6-3H]- and [U-14C]glucose).
  • Rats received either a bolus injection or a continuous infusion of PAF.
  • Adrenergic blockade was induced using propranolol and phentolamine in separate experiments.

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Main Results:

  • PAF bolus injection transiently decreased blood pressure and increased plasma glucose and lactate.
  • PAF administration, both bolus and infusion, dose-dependently increased glucose appearance rate (Ra) and plasma glucose levels.
  • PAF infusions elevated plasma glucagon and catecholamine levels, which were prevented by adrenergic blockade.

Conclusions:

  • PAF administration can induce alterations in glucose metabolism similar to those observed in endotoxemia.
  • The effects of PAF on glucose kinetics and hyperglucagonemia are mediated through adrenergic pathways.
  • This study highlights PAF's role as a potential mediator in endotoxin-induced metabolic disturbances.