Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Autoregulation in the developing postnatal intestinal circulation.

P T Nowicki¹, C E Miller

¹Department of Pediatrics, Ohio State University, Columbus.

The American Journal of Physiology

|February 1, 1988

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The Ornaments of the Arma Veirana Early Mesolithic Infant Burial.

Journal of archaeological method and theory·2023

Same author

Intrinsic Dimensionality as a Metric for the Impact of Mission Design Parameters.

Journal of geophysical research. Biogeosciences·2022

Same author

Pointing in a different direction: a case of bilateral absence of extensor indicis.

Folia morphologica·2021

Same author

Evaluation of internet derived patient information for Acute Pancreatitis.

The Ulster medical journal·2021

Same author

Is transvaginal contained tissue extraction for everyone?

BJOG : an international journal of obstetrics and gynaecology·2017

Same author

Review and Outcomes of Power Morcellation Using an Innovative Contained Bag System.

Journal of minimally invasive gynecology·2016

Same journal

Blood coagulation in fish.

The American journal of physiology·2011

Same journal

Renal tubular reabsorption, metabolic utilization and isomeric fractionation of lactic acid in the dog.

The American journal of physiology·2010

Same journal

The inactivation of placental toxin by human serum.

The American journal of physiology·2010

Same journal

Adrenal function following ovariectomy in the rat.

The American journal of physiology·2010

Same journal

Capillary permeability; perfusion of frog and guinea pig hind limbs.

The American journal of physiology·2010

Same journal

Evaluation of protective measures against sunburn.

The American journal of physiology·2010

See all related articles

Young swine ileal loops show higher blood flow but lack pressure-flow autoregulation compared to older swine. Intestinal oxygenation regulation improves with postnatal age.

Area of Science:

Physiology
Gastroenterology
Neonatal Research

Background:

Intestinal blood flow and oxygenation are critical for neonatal gut health.
Understanding the developmental changes in intestinal hemodynamics is essential for clinical care.

Purpose of the Study:

To investigate the relationship between perfusion pressure, blood flow, and oxygen uptake in swine ileal loops.
To compare the autoregulatory capacity of intestinal circulation in neonatal versus older swine.

Main Methods:

Utilized an in vitro reservoir perfusion apparatus for swine ileal loops.
Standardized blood hematocrit, oxygen, and carbon dioxide levels.
Manipulated perfusion pressure to assess pressure-flow relationships and oxygen uptake.

Related Experiment Videos

Main Results:

3-day-old swine ileal loops exhibited higher blood flow and lower arteriovenous oxygen difference than 35-day-old swine.
Oxygen uptake was not significantly different between age groups.
Pressure-flow autoregulation and oxygen uptake maintenance during pressure reduction were observed in older but not younger swine.

Conclusions:

Neonatal swine ileal loops have immature pressure-flow autoregulation.
Postnatal age significantly influences the intrinsic regulation of intestinal hemodynamics and oxygenation.
Developmental immaturity impacts the gut's ability to maintain oxygenation under reduced perfusion pressure.