Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration01:28

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration

80
Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area.
80
Glomerular Filtration Rate and its Regulation01:28

Glomerular Filtration Rate and its Regulation

4.4K
The Glomerular Filtration Rate (GFR) is a measure of kidney function, reflecting the volume of filtrate formed per minute in the kidneys. On average, GFR is approximately 125 mL/min in males and 105 mL/min in females. Maintaining a relatively constant GFR is essential for the kidneys to effectively regulate body fluid homeostasis and maintain extracellular stability.
GFR regulation involves two primary intrinsic controls: the myogenic and tubuloglomerular feedback mechanisms.
The myogenic...
4.4K
Drug Dosing in Renal Diseases: Dose Adjustments Based on Drug Clearance and Elimination Rate Constant01:25

Drug Dosing in Renal Diseases: Dose Adjustments Based on Drug Clearance and Elimination Rate Constant

80
In patients with renal disease, dosage adjustments are necessary to maintain therapeutic plasma drug concentrations and prevent toxicity or subtherapeutic exposure. Renal impairment alters drug pharmacokinetics, especially in conditions like uremia, where changes such as prolonged elimination half-life and altered apparent volume of distribution can significantly affect drug disposition. These changes require careful modification of the dosing regimen to achieve the desired clinical...
80
Renal Drug Excretion: Glomerular Filtration01:02

Renal Drug Excretion: Glomerular Filtration

843
The kidney serves as the primary organ responsible for eliminating drugs and their metabolites from the body. This process, known as renal elimination, starts with glomerular filtration and results in urine formation. Each kidney houses millions of functional units called nephrons, where urine production occurs. A nephron has two main components: a renal corpuscle and a renal tubule.
Drugs gain access to the kidney via the renal artery, which progressively branches off into afferent arterioles....
843
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

146
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
146
Renal Failure: Dose Adjustments01:11

Renal Failure: Dose Adjustments

248
In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
248

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lactate Metabolism Dysregulation Drives the Pathogenesis of Acute Kidney Injury.

Metabolites·2026
Same author

Aldosterone fuels the progression of cardiovascular-kidney -metabolic syndrome: focus on primary aldosteronism spectrum.

Endocrine·2026
Same author

Interaction and Joint Effects of Inflammation and Triglyceride-Glucose (TyG) Index on Hyperuricemia Risk and the Mediating Role of TyG: A Cross-Sectional Study.

Endocrinology, diabetes & metabolism·2026
Same author

Association of serum melatonin with dietary patterns and dietary nutrients in chinese population: a cross-sectional study.

European journal of nutrition·2025
Same author

Development and Validation of a High-performance Liquid Chromatography-Tandem Mass Spectrometry Method for Detecting Adrenocortical Hormones and Establishment of Age-stratified Reference Intervals in Reproductive-aged Women from Guangxi, China.

Annals of laboratory medicine·2025
Same author

Effect of GLP-1 RA and SGLT2I on Biomarkers of Oxidative Stress in T2DM: A Systematic Review and Meta-analysis.

Journal of the Endocrine Society·2025
Same journal

Paroxysmal Cold Haemoglobinuria: A Chilling Case of Acute Renal Failure.

Nephrology (Carlton, Vic.)·2026
Same journal

Optimising Therapeutic Target Attainment in Vancomycin Therapy for Patients Requiring Intermittent Haemodialysis.

Nephrology (Carlton, Vic.)·2026
Same journal

Injury to E- and VE-Cadherin in Paediatric Idiopathic Steroid-Sensitive Nephrotic Syndrome: Potential Markers of the Disease Status.

Nephrology (Carlton, Vic.)·2026
Same journal

Finerenone in Treating a 12-Year-Old Boy Suffering Gitelman Syndrome Without Causing Gynecomastia.

Nephrology (Carlton, Vic.)·2026
Same journal

NCOA4-Mediated Ferroptosis Drives Tubulointerstitial Fibrosis in Hyperuricemia-Associated Chronic Kidney Disease.

Nephrology (Carlton, Vic.)·2026
Same journal

Comment on 'Chronic Kidney Disease-Associated Pruritus in Patients on Home Haemodialysis'.

Nephrology (Carlton, Vic.)·2026
See all related articles

Related Experiment Video

Updated: Nov 20, 2025

Highly Sensitive Measurement of Glomerular Permeability in Mice with Fluorescein Isothiocyanate-polysucrose 70
09:16

Highly Sensitive Measurement of Glomerular Permeability in Mice with Fluorescein Isothiocyanate-polysucrose 70

Published on: August 9, 2019

7.1K

Adiponectin affects estimated glomerular filtration rate: A two-sample bidirectional Mendelian randomization study.

Yulan Bai1,2,3,4,5, Zefeng Chen1,2,3,4,5, Zheng Wen1,2,3,4,5

  • 1Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, China.

Nephrology (Carlton, Vic.)
|January 23, 2021
PubMed
Summary
This summary is machine-generated.

Adiponectin (ADPN) causally influences estimated glomerular filtration rate (eGFR), but not vice versa. This finding suggests ADPN may be a therapeutic target for improving kidney function and treating chronic kidney disease.

Keywords:
Mendelian randomizationadiponectinchronic kidney diseaseestimated glomerular filtration rategenetic risk score

More Related Videos

Transcutaneous Assessment of Renal Function in Conscious Rodents
07:18

Transcutaneous Assessment of Renal Function in Conscious Rodents

Published on: March 26, 2016

12.7K
Assessment of Kidney Function in Mouse Models of Glomerular Disease
09:16

Assessment of Kidney Function in Mouse Models of Glomerular Disease

Published on: June 30, 2018

18.2K

Related Experiment Videos

Last Updated: Nov 20, 2025

Highly Sensitive Measurement of Glomerular Permeability in Mice with Fluorescein Isothiocyanate-polysucrose 70
09:16

Highly Sensitive Measurement of Glomerular Permeability in Mice with Fluorescein Isothiocyanate-polysucrose 70

Published on: August 9, 2019

7.1K
Transcutaneous Assessment of Renal Function in Conscious Rodents
07:18

Transcutaneous Assessment of Renal Function in Conscious Rodents

Published on: March 26, 2016

12.7K
Assessment of Kidney Function in Mouse Models of Glomerular Disease
09:16

Assessment of Kidney Function in Mouse Models of Glomerular Disease

Published on: June 30, 2018

18.2K

Area of Science:

  • Nephrology
  • Endocrinology
  • Genetics

Background:

  • The relationship between adiponectin (ADPN) and estimated glomerular filtration rate (eGFR) remains unclear.
  • Investigating this relationship is crucial for understanding kidney disease progression.

Purpose of the Study:

  • To explore the potential causal relationship between ADPN and eGFR using a bidirectional Mendelian randomization (MR) approach.
  • To determine if ADPN influences eGFR or if eGFR affects ADPN levels.

Main Methods:

  • Employed a two-sample bidirectional MR study design.
  • Utilized eight single nucleotide polymorphisms (SNPs) for ADPN and 26 SNPs for eGFR as instrumental variables.
  • Applied MR-inverse variance weighted (IVW), MR-Egger, and weighted median methods for analysis, alongside genetic risk score (GRS) analysis.

Main Results:

  • Adiponectin (ADPN) demonstrated a significant causal effect on estimated glomerular filtration rate (eGFR) (IVW: β = .016, P = .002).
  • A 10% increase in ADPN was associated with a 0.15% increase in eGFR.
  • No significant causal effect of eGFR on ADPN was observed (All P values > 0.05).
  • Sensitivity analyses indicated some heterogeneity but no directional pleiotropy.

Conclusions:

  • Adiponectin exerts a causal influence on eGFR.
  • eGFR does not appear to have a causal effect on ADPN.
  • ADPN presents a potential clinical target for enhancing eGFR and managing chronic kidney disease.