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Related Concept Videos

Experimental RNAi02:15

Experimental RNAi

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RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
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Types of RNA01:23

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Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
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siRNA - Small Interfering RNAs02:30

siRNA - Small Interfering RNAs

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Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
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Regulated mRNA Transport02:22

Regulated mRNA Transport

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In eukaryotes, transcription and translation are compartmentalized; an mRNA is first synthesized in the nucleus and then selectively transported to the cytoplasm for protein synthesis. Before transport, a pre-mRNA undergoes several steps of post-transcriptional modifications including splicing, 5' capping, and the addition of a poly-adenine tail. Various proteins bind to the pre-mRNA during these modifications. The mRNA transport takes place with the help of multiple proteins playing...
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RNA Interference01:23

RNA Interference

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RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
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lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Updated: Nov 20, 2025

Identification of Circular RNAs using RNA Sequencing
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Identification of Circular RNAs using RNA Sequencing

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Circular RNAs: Expression, localization, and therapeutic potentials.

Qiwei Yang1, Feiya Li2, Alina T He3

  • 1Sunnybrook Research Institute, Toronto, ON, Canada; Medical Research Center, Second Hospital of Jilin University, Changchun, China; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M4N 3M5, Canada.

Molecular Therapy : the Journal of the American Society of Gene Therapy
|January 23, 2021
PubMed
Summary
This summary is machine-generated.

Circular RNAs (circular RNA) play key roles in non-cancer diseases, particularly cardiovascular diseases. These molecules show potential as biomarkers and therapeutic targets for various conditions.

Keywords:
biomarkercardiovascularcircRNAscircular RNAstherapeutictranslocation

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Area of Science:

  • Molecular Biology
  • Genetics
  • Biochemistry

Background:

  • Circular RNAs (circRNAs) are RNA molecules with a unique circular structure formed by back-splicing.
  • Initially overlooked, circRNAs are now recognized for significant regulatory functions beyond being splicing byproducts.
  • While extensively studied in cancer, their roles in non-cancer diseases are increasingly being explored.

Purpose of the Study:

  • To review the role of circRNAs in non-cancer diseases, with a specific focus on cardiovascular diseases.
  • To provide insights into studying circRNA-protein interactions and their impact on protein translocation.
  • To highlight the potential of circRNAs as biomarkers, therapeutic targets, and treatments in non-cancerous conditions.

Main Methods:

  • Literature review focusing on circRNAs in non-cancer diseases, especially cardiovascular diseases.
  • Discussion of circRNA biogenesis and life cycle.
  • Exploration of methods for studying circRNA-protein interactions and their functional consequences.

Main Results:

  • Circular RNAs are implicated in the pathogenesis of various non-cancer diseases, including cardiovascular diseases.
  • CircRNA-protein interactions can modulate cellular events such as protein translocation.
  • The study provides practical considerations for investigating these interactions.

Conclusions:

  • Circular RNAs represent promising biomarkers for non-cancer diseases.
  • CircRNAs offer potential as therapeutic targets and treatment strategies for cardiovascular and other non-cancerous conditions.
  • Further research into circRNA functions and interactions is warranted for clinical applications.