Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

180
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
180
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

504
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
504
What is Monogastric Digestion?01:50

What is Monogastric Digestion?

74.1K
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
74.1K
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

454
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
454

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Isolation and characterization of phage vB_KpnS_SXK7 against multidrug-resistant Klebsiella pneumoniae and the mechanism of O-antigen-associated phage resistance.

BMC microbiology·2026
Same author

Latent profiles of actual and perceived motor competence are associated with physical activity and BMI in childhood: a latent profile analysis.

Scientific reports·2026
Same author

Development and Internal Validation of a Clinical Data-Based Machine Learning Web Calculator for Predicting Recurrence in Granulomatous Lobular Mastitis: A Multicenter Retrospective Study.

European journal of breast health·2026
Same author

Mapping Two Decades of Research on Endoscopic Submucosal Dissection in Esophageal Cancer: A Bibliometric and Visual Analysis.

Medical science monitor : international medical journal of experimental and clinical research·2026
Same author

Research on the Highly Efficient and Low-Dose Improvement of Alcohol-Induced Liver Injury by High-Selenium-Content Modified Lycium barbarum Polysaccharides.

Biological trace element research·2026
Same author

Motor competence on children's internalizing problems: The serial mediating effect of peer victimization and social support.

Acta psychologica·2026

Related Experiment Video

Updated: Nov 20, 2025

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota
07:15

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota

Published on: July 31, 2019

10.0K

Crosstalk between PPARs and gut microbiota in NAFLD.

Liwei Wu1, Jingjing Li1, Jiao Feng2

  • 1Department of Gastroenterology, Putuo People's Hospital, Tongji University School of Medicine, Shanghai, 200060, China; Department of Gastroenterology, Shanghai Tenth People'sHospital, Tongji University School of Medicine, Shanghai, 200072, China.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|January 23, 2021
PubMed
Summary

Nonalcoholic fatty liver disease (NAFLD) is a growing global health issue. This review explores how gut microbiota influences NAFLD development via peroxisome proliferator-activated receptors (PPARs).

Keywords:
Gut microbiotaNAFLDPPAR

More Related Videos

Murine Fecal Isolation and Microbiota Transplantation
07:32

Murine Fecal Isolation and Microbiota Transplantation

Published on: May 26, 2023

4.9K
DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat
09:04

DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat

Published on: February 27, 2014

48.2K

Related Experiment Videos

Last Updated: Nov 20, 2025

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota
07:15

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota

Published on: July 31, 2019

10.0K
Murine Fecal Isolation and Microbiota Transplantation
07:32

Murine Fecal Isolation and Microbiota Transplantation

Published on: May 26, 2023

4.9K
DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat
09:04

DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat

Published on: February 27, 2014

48.2K

Area of Science:

  • Hepatology
  • Gastroenterology
  • Metabolic Syndrome

Background:

  • Nonalcoholic fatty liver disease (NAFLD) is the most prevalent liver disorder globally, progressing from simple steatosis to severe conditions like cirrhosis and hepatocellular carcinoma (HCC).
  • NAFLD and its complications represent a significant societal health burden.
  • The gut microbiota acts as a crucial factor in host physiology and pathology, influencing overall health homeostasis.

Purpose of the Study:

  • To review and synthesize current research on the interplay between gut microbiota, peroxisome proliferator-activated receptors (PPARs), and NAFLD.
  • To provide a comprehensive overview of how gut microbiota may contribute to NAFLD pathogenesis through PPAR signaling pathways.

Main Methods:

  • Literature review integrating studies on gut microbiota composition and function in NAFLD.
  • Analysis of research investigating the role of PPARs in metabolic regulation and liver disease.
  • Synthesis of evidence linking microbial metabolites and PPAR activation in the context of NAFLD.

Main Results:

  • Gut microbiota alterations are associated with NAFLD progression.
  • PPARs are key regulators of lipid metabolism and inflammation, making them therapeutic targets for NAFLD.
  • Evidence suggests microbial metabolites can modulate PPAR activity, influencing NAFLD development.

Conclusions:

  • The gut microbiota plays a significant role in the pathogenesis of NAFLD.
  • Targeting the gut microbiota and PPAR pathways offers potential therapeutic strategies for NAFLD.
  • Further research is needed to fully elucidate the complex interactions between microbiota, PPARs, and NAFLD.