Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

REM Sleep Behavior Disorder

REM Sleep Behavior Disorder

REM Sleep Behavior Disorder (RBD) is a sleep disorder characterized by the absence of muscle paralysis that normally occurs during the REM phase of sleep. This absence allows individuals to physically act out their dreams, which are often vivid and disturbing. Common behaviors exhibited during episodes include kicking, punching, and yelling. These actions can be dangerous, potentially leading to injuries for the person with RBD or their bed partner.
RBD is significantly associated with...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Extensive dysautonomia in early-stage multiple system atrophy reflects survival differences: insights from data-driven subtypes.

Journal of neurology·2026

Same author

Reply: Genetically proxied GLP1R expression does not predict exenatide response in the Exenatide-PD3 trial.

Brain : a journal of neurology·2026

Same author

Allergic disease as a risk factor for Parkinson's disease: a possible role of eosinophil.

NPJ Parkinson's disease·2026

Same author

Digital Technology for Sleep Symptoms in Parkinson's Disease: A Scoping Review.

Journal of movement disorders·2026

Same author

GLP1R expression and parkinson's disease and related disorders in GLP-1RA-treated type 2 diabetes.

Brain : a journal of neurology·2026

Same author

Longitudinal resting-state EEG-based modeling predicts phenoconversion and delineates heterogeneity in isolated REM sleep behavior disorder.

Research square·2026

Search research articles

Related Experiment Video

Updated: Nov 20, 2025

Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms

Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms

Published on: March 21, 2019

Altered insular functional connectivity in isolated REM sleep behavior disorder: a data-driven functional MRI study.

Jung-Ick Byun¹, Kwang Su Cha², Minah Kim³

¹Department of Neurology, Kyung Hee University Hospital at Gangdong, Kyung Hee University College of Medicine, Seoul, South Korea.

|January 23, 2021

Summary

This summary is machine-generated.

Functional connectivity alterations in the insula and precuneus are linked to isolated rapid eye movement sleep behavior disorder (iRBD) and cognitive function deficits.

Keywords:

Cognitive function Functional brain imaging Multivariate pattern analysis (MVPA)Neuroimaging REM sleep Behavior disorder

More Related Videos

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy

Published on: August 5, 2014

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

Published on: March 14, 2025

Related Experiment Videos

Last Updated: Nov 20, 2025

Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms

Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms

Published on: March 21, 2019

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy

Published on: August 5, 2014

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

Published on: March 14, 2025

Area of Science:

Neuroscience
Sleep Medicine
Brain Imaging

Background:

Functional connectivity (FC) changes may precede structural alterations in neurological disorders.
Isolated rapid eye movement sleep behavior disorder (iRBD) is a prodromal sign of neurodegenerative diseases.
Understanding early neural changes in iRBD is crucial for timely intervention.

Purpose of the Study:

To investigate whole-brain functional connectivity (FC) patterns in iRBD using multivariate pattern analysis (MVPA).
To identify specific brain regions associated with iRBD and their correlation with clinical features.

Main Methods:

Cross-sectional study involving 50 iRBD patients and 20 controls.
Utilized MVPA within the CONN toolbox for data-driven seed region identification.
Performed seed-to-voxel FC analysis and correlated findings with cognitive, mood, and sleep assessments.

Main Results:

MVPA identified a significant cluster in the left posterior insular cortex.
iRBD patients exhibited reduced FC between the insula and precuneus compared to controls.
The degree of FC reduction correlated with cognitive scores (MoCA-K).

Conclusions:

The insula is a key neural correlate in iRBD.
Altered insula-precuneus connectivity is associated with cognitive impairment in iRBD.
These findings highlight potential early biomarkers for iRBD progression.