Related Experiment Video
Updated: Nov 20, 2025

Creating and Applying a Reference to Facilitate the Discussion and Classification of Proteins in a Diverse Group
Published on: August 16, 2017
Considerations for conducting systematic reviews: evaluating the performance of different methods for de-duplicating
Sandra McKeown1, Zuhaib M Mir2
1Bracken Health Sciences Library, Queen's University, 18 Stuart Street, Kingston, Ontario, K7L 2V5, Canada. sandra.mckeown@queensu.ca.
Ovid, Covidence, and Rayyan showed the highest accuracy in de-duplicating references for systematic reviews. Ovid and Covidence excelled in specificity, while Rayyan led in sensitivity for duplicate identification.
Area of Science:
- Information Science
- Medical Informatics
- Bibliometrics
Background:
- Systematic reviews require comprehensive searches across multiple databases.
- Electronic platforms enhance efficiency and quality in evidence synthesis.
- Accurate de-duplication of references is crucial for systematic review integrity.
Purpose of the Study:
- To evaluate the accuracy and efficiency of common electronic de-duplication methods.
- To compare the performance of various software tools in identifying duplicate references.
- To inform the selection of de-duplication tools for systematic reviews.
Main Methods:
- A reference set was created by searching MEDLINE, Embase, Cochrane, and PsycINFO.
- Manual abstraction established a benchmark set for de-duplication.
- Ovid multifile search, EndNote, Mendeley, Zotero, Covidence, and Rayyan were tested using default settings.
Main Results:
- Ovid, Covidence, and Rayyan were the most accurate de-duplication methods.
- Ovid and Covidence demonstrated the highest specificity.
- Rayyan exhibited the highest sensitivity in identifying duplicate references.
Conclusions:
- Understanding the strengths and weaknesses of de-duplication tools is vital.
- Strategies to improve de-duplication performance can prevent bias and loss of studies.
- Factors like accuracy, ease-of-use, and functionality should guide software selection for systematic reviews.
Related Concept Videos
Data Validation
Key parameters for method validation include:
Systematic Error: Methodological and Sampling Errors
Sampling errors originate from improper sampling methods or the wrong sample population. These errors can be minimized by refining the sampling strategy. Defective instruments or faulty calibrations are the sources of instrumental...
Comparing Copy Number Variations and SNPs
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
Bioequivalence Experimental Study Designs: Repeated Measures, Cross-Over, Carry-Over, and Latin Square Designs
Gene Conversion
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...

