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Related Concept Videos

Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

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The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
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Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

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After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
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Related Experiment Video

Updated: Nov 20, 2025

Generation of 3D Skin Organoid from Cord Blood-derived Induced Pluripotent Stem Cells
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Generation of 3D Skin Organoid from Cord Blood-derived Induced Pluripotent Stem Cells

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Two-Stage Patterned Cell-Based Treatments for Skin Regeneration.

Chih-Long Chen, Chieh-Yi Tsai, Yu-Shan Chen

    Journal of Biomedical Nanotechnology
    |January 24, 2021
    PubMed
    Summary

    This study presents a two-stage treatment for wound healing, combining hydrocolloid dressings and patterned cell-laden hydrogels. This approach promotes skin regeneration, reduces scarring, and restores skin function, offering a promising therapeutic option.

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    Tissue Characterization after a New Disaggregation Method for Skin Micro-Grafts Generation
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    Tissue Characterization after a New Disaggregation Method for Skin Micro-Grafts Generation

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    Area of Science:

    • Biomaterials Science
    • Regenerative Medicine
    • Wound Healing Research

    Background:

    • Scarring and aligned collagen formation impede native skin regeneration.
    • The interplay between inflammation and regeneration complicates wound healing outcomes.
    • Fetal wound healing offers a model for scarless repair.

    Purpose of the Study:

    • To develop a two-stage therapeutic strategy inspired by fetal wound healing.
    • To investigate the efficacy of patterned cell-laden hydrogels for enhanced skin regeneration.
    • To explore the mechanisms underlying improved wound healing with this novel treatment.

    Main Methods:

    • A two-stage treatment combining hydrocolloid dressings and patterned cell-laden hydrogels.
    • Fabrication of patterned cell-laden hydrogels using photolithography.
    • Evaluation of skin regeneration in a full-thickness murine wound model.

    Main Results:

    • The treatment promoted vascular network formation and accelerated wound closure.
    • Scar formation was decreased, while tissue regeneration and skin properties were restored.
    • The patterned cell-based therapy demonstrated significant improvements in wound healing efficacy.

    Conclusions:

    • The developed two-stage patterned cell-laden hydrogel treatment is a promising therapeutic option for wound healing.
    • This approach effectively enhances skin regeneration and restores tissue structure and function.
    • The strategy addresses key challenges in achieving scar-free skin repair.