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Related Experiment Video

Updated: Nov 20, 2025

An Alkali-burn Injury Model of Corneal Neovascularization in the Mouse
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Systemic diseases and the cornea.

Ruchi Shah1, Cynthia Amador1, Kati Tormanen2

  • 1Eye Program, Board of Governors Regenerative Medicine Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Experimental Eye Research
|January 24, 2021
PubMed
Summary

Systemic diseases can manifest in the cornea, serving as early indicators of serious health conditions. This review details corneal changes in various systemic diseases and discusses treatments.

Keywords:
Addison's diseaseAniridiaAutoimmune diseaseCorneal deposit disorderDiabetic corneaEhlers-Danlos syndromeGenetic corneal diseaseGraves' diseaseHerpesImmunobullous diseaseInflammationKeratoconjunctivitisMarfan syndromePseudomonas aeruginosaSARS-CoV-2Sjögren's syndromeSyphilisTuberculosisZoster

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Area of Science:

  • Ophthalmology
  • Internal Medicine
  • Pathology

Background:

  • Systemic diseases frequently impact the cornea.
  • Corneal manifestations can be the initial sign of undiagnosed systemic conditions.
  • Routine eye examinations are crucial for detecting potentially severe illnesses.

Purpose of the Study:

  • To review pathological corneal changes associated with systemic diseases.
  • To discuss the molecular mechanisms underlying these changes.
  • To explore current and emerging treatment strategies.

Main Methods:

  • Literature review of systemic diseases affecting the cornea.
  • Analysis of pathological changes and molecular mechanisms.
  • Overview of therapeutic interventions.

Main Results:

  • Corneal involvement is noted in endocrine, infectious, autoimmune, inflammatory, genetic, and deposit disorders.
  • Specific examples include diabetes, viral infections, rheumatoid arthritis, and Fabry disease.
  • Corneal findings offer insights into systemic pathology.

Conclusions:

  • Corneal manifestations are vital diagnostic clues for systemic diseases.
  • Understanding molecular pathways aids in developing targeted therapies.
  • Comprehensive eye exams play a key role in early disease detection and management.