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Enterohepatic circulation of NY-198, a new difluorinated quinolone, in rats
A Saito1, O Nagata, Y Takahara
1College of Medical Technology, Hokkaido University, Sapporo, Japan.
Antimicrobial Agents and Chemotherapy
|January 1, 1988
Abstract:
Enterohepatic circulation of NY-198 in rats was studied. NY-198 glucuronide in the bile was rapidly hydrolyzed to NY-198 by the intestinal contents. Hydrolyzed and parent NY-198 in the bile were reabsorbed from the intestine. The amount of NY-198 in enterohepatic circulation was 59.8% of that excreted in the bile.