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Updated: Nov 20, 2025

A Static Self-Directed Method for Generating Brain Organoids from Human Embryonic Stem Cells

A Static Self-Directed Method for Generating Brain Organoids from Human Embryonic Stem Cells

Published on: March 4, 2020

Biomaterial-guided stem cell organoid engineering for modeling development and diseases.

Plansky Hoang¹, Zhen Ma¹

¹Department of Biomedical and Chemical Engineering, Syracuse University, NY, United States; BioInspired Syracuse Institute for Material and Living Systems, NY, United States.

Acta Biomaterialia

|January 24, 2021

Summary

Organoid engineering uses biomaterials and microfabrication to create miniature organ models. These advanced organoid systems enable in vitro study of human development and disease, paving the way for therapeutic applications.

Keywords:

Biomaterials Organoids Self-organization Spatial patterning Stem cell engineering

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A Human Cerebral Organoid Model of Neural Cell Transplantation

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Published on: July 21, 2023

Area of Science:

Biotechnology
Developmental Biology
Tissue Engineering

Background:

Organoids, miniature organ models, recapitulate in vivo cellular organization and function.
Organoid technology has transformed developmental biology, enabling in vitro study of human development and diseases.
Biomaterial-based culture systems enhance organoid production consistency and reproducibility.

Purpose of the Study:

To review enabling technologies for organoid engineering.
To discuss controlling biochemical and biophysical cues for organoid development.
To explore therapeutic applications of enhanced organoid systems.

Main Methods:

Hydrogels for controlling biochemical and biophysical cues.
Microwell and microfabrication techniques for size and geometry control.
Biofabrication and organoid-on-chip platforms for complex system assembly.

Main Results:

Engineered tissue microenvironments promote spatial patterning and morphogenesis in organoids.
Advanced techniques allow for consistent and reproducible organoid production.
Organoid-on-chip platforms facilitate complex in vitro modeling.

Conclusions:

Organoid engineering is crucial for studying development and disease.
Tailoring the cellular microenvironment is key to organoid formation and function.
Future perspectives focus on building improved organoid systems for therapeutic applications.