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Dynamic measurement of amnion thickness during loading by speckle pattern interferometry.

Tong Zhang1, Yan Zhang2, Jianhong Yang3

  • 1Institute of Solid Mechanics, School of Aeronautics Sciences and Engineering, Beihang University, Beijing, 100083, China.

Placenta
|January 24, 2021
PubMed
Summary

Researchers developed a novel method to accurately measure amnion (AM) thickness during mechanical testing. This enables precise determination of AM mechanical properties, like fracture energy density and rupture modulus, crucial for predicting pregnancy complications.

Keywords:
Amnion rupture modulusDynamic thickness measurementFracture energy densityPPROMSpeckle pattern interferometry

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Obstetrics

Background:

  • Accurate measurement of amnion (AM) mechanical properties is vital for understanding pregnancy complications.
  • Previous studies lacked precise AM thickness measurements, hindering accurate mechanical characterization.

Purpose of the Study:

  • To develop and validate a method for accurate in-situ measurement of AM thickness during mechanical testing.
  • To determine key mechanical parameters of the human amnion, including fracture energy density and rupture modulus.

Main Methods:

  • Estimated initial AM thickness using the interpolated-volume-area method.
  • Employed a self-developed mini-biaxial tensile device combined with speckle pattern interferometry for real-time thickness measurement.
  • Obtained accurate stress-strain curves from tensile testing.

Main Results:

  • Successfully obtained accurate stress-strain curves for human amnion.
  • Extracted key mechanical parameters: fracture energy density (0.184±0.036 MPa) and amnion rupture modulus (108.57±17.32 MPa).
  • Observed a distinct J-shape in the tensile stress-strain curve, confirming experimental reliability.

Conclusions:

  • The developed method allows for accurate determination of AM mechanical properties.
  • Fracture energy density and amnion rupture modulus provide objective criteria for evaluating AM rupture.
  • These parameters are critical for the evaluation and prediction of rupture of membranes (ROM), preterm premature rupture of membranes (PPROM), and preterm rupture of membranes (PROM).