Related Experiment Videos
Acrocyanosis due to imipramine.
1Otago University Medical School, Dunedin, New Zealand.
Archives of Disease in Childhood
|February 1, 1988
Summary
Imipramine treatment for enuresis caused acrocyanosis in an 11-year-old girl. Discontinuation of imipramine led to rapid recovery, suggesting a link between the drug and the condition.
Area of Science:
- Pediatric Pharmacology
- Clinical Toxicology
Background:
- Enuresis is common in children and can be treated with medications like imipramine.
- Imipramine is a tricyclic antidepressant with various physiological effects.
Observation:
- An 11-year-old girl presented with acrocyanosis (bluish discoloration) of her hands and feet.
- This adverse effect emerged during treatment for enuresis with imipramine.
Findings:
- Biochemical and hematological tests were within normal limits, ruling out common causes of acrocyanosis.
- Cessation of imipramine resulted in complete resolution of acrocyanosis within three days.
Implications:
- This case highlights a potential adverse reaction of imipramine, specifically acrocyanosis, in pediatric patients.
- Clinicians should consider imipramine-induced acrocyanosis in children presenting with peripheral cyanosis during treatment.
- Further investigation may be warranted to understand the mechanism of imipramine-related peripheral vascular effects.