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Updated: Nov 20, 2025

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Small GTPases all over invadosomes

Paul Rivier1, Michel Mubalama1, Olivier Destaing1

  • 1Team DYSAD, Dept2, Institute for Advanced Biosciences, Centre de Recherche Université Grenoble Alpes, Inserm U 1209, CNRS UMR 5309, Grenoble, France.

Small Gtpases
|January 25, 2021
PubMed

Cell invasion is associated with numerous patho-physiologic states including cell development and metastatic dissemination. This process couples the activation of cell motility with the capacity to degrade the extracellular matrix, thereby permitting cells to pass through basal membranes. Invasion is sustained by the actions of invadosomes, an ensemble of subcellular structures with high functional homology. Invadosomes are 3D acto-adhesive structures that can also mediate local extracellular matrix degradation through the controlled delivery of proteases. Intracellular RHO GTPases play a central role in the regulation of invadosomes where their complex interplay regulates multiple invadosome functions. This review aims to provide an overview of the synergistic activities of the small GTPases in invadosome biology. This broad-based review also reinforces the importance of the spatiotemporal regulation of small GTPases and the impact of this process on invadosome dynamics.

Keywords:
Small GTPaseinvadopodiainvadosomeslinear invadosomespodosomesspatiotemporal signalling

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