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Related Experiment Videos

Clonidine effect on spasticity: a clinical trial.

W H Donovan1, R E Carter, C D Rossi

  • 1Institute for Rehabilitation and Research, Houston, TX 77030.

Archives of Physical Medicine and Rehabilitation
|March 1, 1988
PubMed
Summary

Clonidine as an adjunct to baclofen effectively treated spasticity in over half of spinal cord injury patients. Response rates varied by injury type, with fewer side effects observed.

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Rehabilitation Medicine

Background:

  • Spasticity is a common and debilitating symptom following spinal cord injury (SCI).
  • Baclofen is a standard treatment, but its efficacy can be limited.
  • Adjunctive therapies are needed to improve spasticity management in SCI patients.

Purpose of the Study:

  • To evaluate the efficacy and safety of clonidine as an adjunct to baclofen for managing spasticity in patients with spinal cord injury.
  • To determine response rates based on patient subgroups (quadriplegics vs. paraplegics, complete vs. incomplete lesions).

Main Methods:

  • A study involving 55 patients with spasticity secondary to spinal cord injury.
  • Patients received clonidine as an adjunct to their existing baclofen therapy.

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  • Dosage of clonidine was titrated to the minimum effective amount.
  • Patients were categorized into quadriplegic or paraplegic groups with complete or incomplete lesions.

    • Main Results:

    • Overall, 56% (31 out of 55) of patients showed benefit from the addition of clonidine.
    • Quadriplegic patients demonstrated higher response rates (64% complete, 68% incomplete lesions) compared to paraplegics (40% complete, 25% incomplete lesions).
    • Adverse effects were minimal, primarily postural hypotension, requiring dosage adjustment in three patients.

    Conclusions:

    • Clonidine can be an effective adjunctive treatment for spasticity in spinal cord injury patients, particularly quadriplegics.
    • The drug is generally well-tolerated, with manageable side effects.
    • Further research may explore optimized dosing strategies for different SCI patient profiles.