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Hand-Foot Skin Reaction with Sunitinib: A Rare Case Report with Review of Literature
Suchibrata Das1, Alok K Roy1, Srutee Barman1
1Department of Dermatology, Venereology and Leprosy, NRS Medical College, 138 AJC Bose Road, Kolkata, West Bengal, India.
Abstract:
Newer multi-kinase inhibitors (MKI) like sunitinib have changed the therapy of patients of renal cell carcinoma, hepatocellular carcinoma, and gastrointestinal stromal tumor. The use of sunitinib also led to cutaneous toxicity, known as hand-foot skin reaction (HFSR). We report a case of hand-foot skin reaction (HFSR) in an Indian patient being treated with sunitinib. Respective literature on this disorder is also reviewed.
Insights
Sunitinib, a multi-kinase inhibitor, effectively treats certain cancers but can cause hand-foot skin reaction (HFSR). This case report details HFSR in an Indian patient receiving sunitinib, with a review of existing literature on this side effect.
Area of Science:
- Oncology
- Dermatology
- Pharmacology
Background:
- Multi-kinase inhibitors (MKIs) like sunitinib have revolutionized cancer treatment.
- Sunitinib is used for renal cell carcinoma, hepatocellular carcinoma, and gastrointestinal stromal tumors.
- A known side effect of sunitinib is cutaneous toxicity, specifically hand-foot skin reaction (HFSR).
Observation:
- This report presents a case of hand-foot skin reaction (HFSR) in an Indian patient receiving sunitinib treatment.
- The observed HFSR highlights a common adverse event associated with this targeted cancer therapy.
Findings:
- Sunitinib-induced hand-foot skin reaction (HFSR) is a prevalent dermatological side effect in cancer patients.
- The case underscores the importance of recognizing and managing HFSR in diverse patient populations undergoing MKI treatment.
Implications:
- Understanding and managing sunitinib-induced HFSR is crucial for maintaining treatment adherence and patient quality of life.
- This case contributes to the literature on MKI-related toxicities, particularly in Indian demographics, informing clinical practice and future research.
