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COVID-19: A challenge for electrochemical biosensors
Jiri Kudr1, Petr Michalek1,2, Lada Ilieva1
1Department of Chemistry and Biochemistry, Mendel University in Brno, Zemedelska 1, CZ-613 00, Brno, Czech Republic.
Trends in Analytical Chemistry : TRAC
|January 25, 2021
Summary
This review highlights electrochemical biosensors as promising tools for rapid, low-cost COVID-19 diagnostics. These sensors offer a user-friendly alternative to traditional methods for detecting SARS-CoV-2 infection.
Area of Science:
- Biomedical Engineering
- Infectious Disease Diagnostics
- Electrochemistry
Background:
- The COVID-19 pandemic, caused by SARS-CoV-2, necessitates advanced diagnostic solutions.
- Current diagnostic methods like qRT-PCR face limitations in speed, cost, and user-friendliness.
- There is a critical need for rapid, accessible, and reliable SARS-CoV-2 detection tools.
Purpose of the Study:
- To critically review viral electrochemical biosensors for COVID-19 diagnosis.
- To outline SARS-CoV-2 properties relevant to biosensor development.
- To discuss the advantages and disadvantages of current diagnostic techniques.
Main Methods:
- Focus on electrochemical biosensors for detecting viral nucleic acid and whole viral particles.
- Critical analysis of existing diagnostic methods, including qRT-PCR.
- Review of molecular and biochemical attributes of SARS-CoV-2 infection.
Main Results:
- Electrochemical biosensors show significant promise for rapid COVID-19 diagnostics.
- These biosensors offer potential for low-cost, user-friendly, and on-site detection.
- Comparison highlights limitations of conventional methods versus biosensor advantages.
Conclusions:
- Electrochemical biosensors represent a viable and emerging technology for SARS-CoV-2 detection.
- Further development is needed to optimize these biosensors for widespread clinical use.
- Future research should focus on enhancing sensitivity, specificity, and integration into diagnostic workflows.
