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Updated: Nov 20, 2025

Non-Invasive Visualization of Nailbed Microvascular Morphology in Mice Using Capillaroscopy

Non-Invasive Visualization of Nailbed Microvascular Morphology in Mice Using Capillaroscopy

Published on: February 28, 2025

Nailfold capillaroscopy in psoriasis.

M Sivasankari¹, Sandeep Arora², Vivek Vasdev³

¹Graded Specialist (Dermatology), Military Hospital Jodhpur, India.

Medical Journal, Armed Forces India

|January 25, 2021

Summary

This summary is machine-generated.

Nailfold capillaroscopy (NFC) reveals microvascular abnormalities in psoriasis patients, with reduced capillary density and altered morphology. These findings correlate with disease severity and can aid in prognosis and treatment monitoring.

Keywords:

Nailfold capillaroscopy Psoriasis Psoriatic arthritis

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A Reproducible Computerized Method for Quantitation of Capillary Density using Nailfold Capillaroscopy

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Non-invasive Assessment of Microvascular and Endothelial Function

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Published on: January 29, 2013

Area of Science:

Dermatology
Rheumatology
Medical Imaging

Background:

Psoriasis is a chronic inflammatory skin disease associated with microcirculatory changes.
Nailfold capillaroscopy (NFC) is increasingly recognized for its utility in assessing psoriasis.
Microvascular alterations in psoriasis may precede skin lesions and correlate with disease severity.

Purpose of the Study:

To investigate nailfold capillaroscopic findings in patients diagnosed with psoriasis.
To evaluate the potential of NFC as a tool for prognostication and follow-up in psoriasis.

Main Methods:

A cross-sectional observational study was conducted involving patients with psoriasis.
Nailfold capillaroscopy was performed using a digital capillaroscope to analyze capillary morphology.
Statistical analysis included independent-samples t test and chi-square test to assess variable relationships.

Main Results:

Subnormal capillary loop density (<9 capillaries/mm) was observed in 96% of patients.
Abnormal capillary morphology, including bizarre shapes and crossed/tortuous loops, was prevalent (15.5% and 17.3%, respectively).
Irregular capillary distribution correlated with widespread disease and psoriatic arthritis (p < 0.001).

Conclusions:

Nailfold capillaroscopy is a simple, non-invasive tool for evaluating microcirculation in psoriasis.
NFC findings correlate with psoriasis disease severity and can be used for patient follow-up.
NFC can serve as a prognostic indicator for disease progression or treatment response.