The Reconstruction of a 12-Lead Electrocardiogram from a Reduced Lead Set Using a Focus Time-Delay Neural Network

The 12-lead electrocardiogram (ECG) is the gold-standard ECG method used by cardiologists. However, accurate electrode placement is difficult and time consuming, and can lead to incorrect interpretation.

The objective of this study was to accurately reconstruct a full 12-lead ECG from a reduced lead set.

Five-electrode placement was used to generate leads I, II, III, aVL, aVR, aVF and V2. These seven leads served as inputs to the focus time-delay neural network (FTDNN) which derived the remaining five precordial leads (V1, V3-V6). An online archived medical database containing 549 cases of ECG recordings was used to train, validate and test the FTDNN.

After removing outliers, the reconstructed leads exhibited correlation values of between 0.8609 and 0.9678 as well as low root mean square error values of between 123 μV and 245 μV across all cases, for both healthy controls and cardiovascular disease subgroups except the bundle branch block disease subgroup. The results of the FTDNN method compared favourably to those of prior lead reconstruction methods.

A standard 12-lead ECG was successfully reconstructed with high quantitative correlations from a reduced lead set using only five electrodes, of which four were placed on the limbs. Less reliance on precordial leads will aid in the reduction of electrode placement errors, ultimately improving ECG lead accuracy and reduce the number of cases that are incorrectly diagnosed.