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The Biological Roles of Exosomal Long Non-Coding RNAs in Cancers

Miao Da1, Hao Jiang1, Yangyang Xie2

  • 1Department of Nursing, Huzhou Third Municipal Hospital, Huzhou, Zhejiang, People's Republic of China.

Oncotargets and Therapy
|January 25, 2021
PubMed

Insights

Exosomal long non-coding RNAs (lncRNAs) are key intercellular communicators in cancer, influencing progression and treatment resistance. Understanding their mechanisms offers new avenues for cancer diagnosis and therapy.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Cancer remains a leading cause of global mortality despite numerous treatments.
  • Exosomes, secreted vesicles, mediate intercellular communication by carrying diverse biomolecules like long non-coding RNAs (lncRNAs).
  • lncRNAs are increasingly recognized as critical regulators of cancer biology.

Purpose of the Study:

  • To review the molecular mechanisms of exosomal lncRNAs in cancer progression, angiogenesis, and chemotherapy resistance.
  • To explore the potential applications of exosomal lncRNAs in cancer diagnosis, treatment, and prognosis.

Main Methods:

  • Literature review focusing on exosomal lncRNAs.
  • Analysis of molecular mechanisms underlying exosomal lncRNA functions in cancer.
  • Synthesis of current research on exosomal lncRNAs for clinical applications.

Main Results:

  • Exosomal lncRNAs act as signaling molecules, influencing cancer cell behavior and the tumor microenvironment.
  • These vesicles can transfer phenotypic traits to recipient cells, impacting cancer progression.
  • Exosomal lncRNAs are implicated in regulating angiogenesis and mediating chemotherapy resistance.

Conclusions:

  • Exosomal lncRNAs play a significant role in cancer development and response to therapy.
  • Further research into exosomal lncRNAs can enhance cancer diagnosis, treatment strategies, and prognostic assessments.
  • Targeting exosomal lncRNAs presents a promising future direction for cancer research and clinical intervention.
Keywords:
cancerexosomelong non-coding RNAs

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