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Related Concept Videos

Mesenchymal Stem Cells01:19

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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
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Mouse Model of Surgical Uterine Injury and Subsequent Pregnancy Outcomes
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Mesenchymal stem cells for restoring endometrial function: An infertility perspective.

Ruttachuk Rungsiwiwut1, Pramuan Virutamasen2, Kamthorn Pruksananonda2

  • 1Department of Anatomy Faculty of Medicine Srinakharinwirot University Bangkok Thailand.

Reproductive Medicine and Biology
|January 25, 2021
PubMed
Summary

Mesenchymal stem cells (MSCs) show promise for treating endometrial infertility by improving uterine function and promoting pregnancy. Adipose- and menstruation-derived MSCs offer advantages for easy derivation and autologous transplantation.

Keywords:
assisted reproductive medicinecell therapyendometriuminfertilitystem cells

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Area of Science:

  • Reproductive Medicine
  • Stem Cell Biology
  • Regenerative Medicine

Background:

  • Mesenchymal stem cells (MSCs) are multipotent cells with differentiation and immunomodulatory properties.
  • MSCs can be sourced from bone marrow, placenta, adipose tissue, and endometrium.
  • Preclinical and clinical studies highlight MSCs' potential in treating female reproductive disorders.

Purpose of the Study:

  • To review the current research on using MSCs for treating endometrial infertility.
  • To explore the mechanisms by which MSCs improve endometrial function.

Main Methods:

  • Literature review focusing on MSCs for endometrial dysfunction-related infertility in women.

Main Results:

  • Various MSC sources (bone marrow, umbilical cord, adipose, amniotic, menstruation) promote endometrial cell proliferation and repair, reducing scarring.
  • Beneficial effects are attributed to immunomodulation, cell differentiation, proliferation stimulation, and fibrosis gene downregulation.
  • MSCs enhance endometrial function, leading to increased implantation and pregnancy rates.

Conclusions:

  • MSCs demonstrate significant potential for treating endometrial infertility.
  • Adipose- and menstruation-derived MSCs are advantageous due to ease of derivation and reduced risk of graft rejection in autologous transplantation.