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Updated: Nov 20, 2025

Evaluation of Intracellular Location of Reactive Oxygen Species in Solea Senegalensis Spermatozoa
10:24

Evaluation of Intracellular Location of Reactive Oxygen Species in Solea Senegalensis Spermatozoa

Published on: March 11, 2018

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Oxidative stress and male infertility

Teppei Takeshima1, Kimitsugu Usui1, Kohei Mori1

  • 1Department of Urology, Reproduction Center Yokohama City University Medical Center Yokohama city Japan.

Reproductive Medicine and Biology
|January 25, 2021
PubMed
Abstract

Insights

Male infertility is often linked to excessive reactive oxygen species (ROS), termed Male Oxidative Stress Infertility (MOSI). Minimizing oxidative stress and diagnosing MOSI are key to improving fertility outcomes.

Area of Science:

  • Reproductive biology
  • Andrology
  • Biochemistry

Background:

  • 30-80% of male infertility cases involve excessive reactive oxygen species (ROS) in ejaculate.
  • Male infertility cause remains unexplained in approximately 50% of cases.
  • Oxidative stress (OS) is strongly linked to male infertility, leading to the proposed term Male Oxidative Stress Infertility (MOSI).

Purpose of the Study:

  • To survey the effects of OS on male infertility.
  • To verify the effects and treatments of OS in male infertility.
  • To highlight the importance of diagnosing MOSI for better clinical outcomes.

Main Methods:

  • PubMed database search for original and review articles.
  • Survey of existing literature on OS and male infertility.
  • Verification of OS effects and potential treatments.

Main Results:

  • Seminal plasma antioxidants protect sperm from ROS; low ROS levels are essential for fertilization.
  • Excessive ROS production causes OS, leading to lipid peroxidation, sperm DNA damage, and apoptosis, thus reducing fertility.
  • Assays like MiOXSYS® can evaluate OS; minimizing OS is crucial for improving clinical outcomes.

Conclusions:

  • Accurate diagnosis of MOSI is vital for effective treatment.
  • Identifying sensitive biomarkers through proteomics technology is essential for improved clinical outcomes in male infertility.
  • Addressing OS is critical for managing and treating male infertility.
Keywords:
antioxidantslipid peroxidationmale infertilityoxidative stressreactive oxygen species

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