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Cortical Thickness in Migraine: A Coordinate-Based Meta-Analysis.

LiQin Sheng¹, HaiRong Ma¹, YuanYuan Shi²

¹Department of Neurology, Kunshan Hospital of Traditional Chinese Medicine, Suzhou, China.

Frontiers in Neuroscience

|January 25, 2021

Summary

This meta-analysis found no consistent cortical thickness differences in migraine patients compared to healthy individuals. Inconsistent findings highlight potential issues in neuroimaging research, like small sample sizes and varied methodologies.

Keywords:

coordinate-based meta-analysis cortical thickness migraine seed-based d mapping with permutation of subject images surface-based morphometry

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Area of Science:

Neuroimaging
Neurology
Brain Morphometry

Background:

Cortical thickness (CTh) studies in migraine show inconsistent results, hindering a clear understanding of brain morphometry.
Coordinate-based meta-analysis (CBMA) can synthesize neuroimaging data to identify consistent brain alterations.

Approach:

A systematic search of multiple databases and sources identified 16 studies (17 datasets) comparing CTh in migraine patients and healthy controls (HCs).
CBMA was performed using the Seed-based d Mapping with Permutation of Subject Images approach.
Sensitivity, subgroup, and metaregression analyses were conducted to ensure robustness and explore potential confounders.

Key Points:

The CBMA revealed no statistically significant consistent CTh alterations in migraine patients versus HCs.
Results remained robust across sensitivity and subgroup analyses.
Metaregression indicated no confounding influence from age, gender, aura, attack frequency, or illness duration.

Conclusions:

The study contributes to the growing evidence of a replication crisis in neuroimaging.
Potential confounders like underpowered samples, heterogeneous criteria, and methodological differences may explain inconsistent CTh findings in migraine.
Future research should address these factors to improve reliability in migraine neuroimaging studies.