Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Anorexia Nervosa01:28

Anorexia Nervosa

399
Anorexia nervosa is a complex and severe eating disorder characterized by an intense fear of weight gain, an unrelenting pursuit of thinness, and a distorted body image. It often leads to dangerously low body weight relative to an individual's age and height. This disorder is marked by significant physical and psychological consequences, making it one of the most life-threatening psychiatric illnesses.
Symptoms and Physical Effects
Individuals with anorexia nervosa commonly exhibit extreme...
399
Bulimia Nervosa01:30

Bulimia Nervosa

356
Bulimia nervosa is a complex and severe eating disorder characterized by a cyclical pattern of binge-and-purge eating pattern. It generally involves an episode of binge eating, followed by compensatory behaviors such as vomiting, excessive exercise, laxative use, or fasting, to prevent weight gain. Despite often maintaining a normal weight, individuals with bulimia are intensely preoccupied with their body image and harbor an overwhelming fear of gaining weight. This can contribute to the...
356
Binge Eating Disorders01:23

Binge Eating Disorders

294
Binge eating disorder is a significant mental health condition characterized by recurrent episodes of excessive food consumption within a short period, accompanied by a perceived loss of control over eating behavior. Unlike occasional overeating, binge eating disorder is marked by distressing emotions such as guilt, shame, and anxiety following binge episodes. The disorder affects individuals across different ages and backgrounds, with profound implications for physical and psychological...
294
Psychosis: Goals of Pharmacotherapy01:26

Psychosis: Goals of Pharmacotherapy

317
Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
317
Treatment Strategies for Psychological Disorders01:24

Treatment Strategies for Psychological Disorders

438
Treatment approaches for psychological disorders fall into three main categories: psychological, biological, and sociocultural. Each approach targets different aspects of mental health, requiring varying levels of education and training.
Psychological therapies focus on modifying emotions, thoughts, and behaviors through talking, interpreting, listening, rewarding, challenging, and modeling. Clinical psychologists, counselors, and social workers commonly practice psychotherapy. Clinical...
438
Antidepressant Drugs: MAOIs and Other Agents01:23

Antidepressant Drugs: MAOIs and Other Agents

603
Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
603

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intravenous Ferric Derisomaltose versus Iron Sucrose for Treatment of Iron Deficiency Anemia in Pregnancy: a Randomized, Comparative Trial.

Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC·2026
Same author

Employing a Coaching Model of Supervision During Physiotherapy Placements: A Qualitative Study of the Practice Educator Experience.

Physiotherapy research international : the journal for researchers and clinicians in physical therapy·2026
Same author

Atraumatic intraneural heterotopic ossification of the common peroneal nerve: illustrative case.

Journal of neurosurgery. Case lessons·2026
Same author

Decline in hip abductor torque, power, and velocity emerges in middle age: age and sex differences across adulthood.

Physiotherapy theory and practice·2026
Same author

British Association of Sexual Health and HIV guidelines on the management of viral hepatitis 2026.

International journal of STD & AIDS·2026
Same author

On the facility of a physiotherapy role-emerging placement scheme in residential care: A qualitative account of the student experience.

Physiotherapy·2026

Related Experiment Video

Updated: Nov 20, 2025

Control of Eating Behavior Using a Novel Feedback System
04:48

Control of Eating Behavior Using a Novel Feedback System

Published on: May 8, 2018

11.3K

Characterizing Treatment-Resistant Anorexia Nervosa.

Sarah Smith1, D Blake Woodside1,2

  • 1Department of Psychiatry, University of Toronto, Toronto, ON, Canada.

Frontiers in Psychiatry
|January 25, 2021
PubMed
Summary
This summary is machine-generated.

Patients with treatment-resistant eating disorders show more severe psychopathology and depressive symptoms upon admission compared to those with good outcomes. This suggests treatment resistance may be distinct from severe and enduring anorexia nervosa, requiring further investigation.

Keywords:
anorexia nervosaeating disorderinpatientpremature termination of treatmenttreatment resistant

More Related Videos

Assessing Activity-based Anorexia in Mice
08:26

Assessing Activity-based Anorexia in Mice

Published on: May 14, 2018

12.8K
A Computer-Based Platform for Aiding Clinicians in Eating Disorder Analysis and Diagnosis
04:19

A Computer-Based Platform for Aiding Clinicians in Eating Disorder Analysis and Diagnosis

Published on: May 10, 2022

4.2K

Related Experiment Videos

Last Updated: Nov 20, 2025

Control of Eating Behavior Using a Novel Feedback System
04:48

Control of Eating Behavior Using a Novel Feedback System

Published on: May 8, 2018

11.3K
Assessing Activity-based Anorexia in Mice
08:26

Assessing Activity-based Anorexia in Mice

Published on: May 14, 2018

12.8K
A Computer-Based Platform for Aiding Clinicians in Eating Disorder Analysis and Diagnosis
04:19

A Computer-Based Platform for Aiding Clinicians in Eating Disorder Analysis and Diagnosis

Published on: May 10, 2022

4.2K

Area of Science:

  • Clinical Psychology
  • Psychiatry
  • Eating Disorder Research

Background:

  • Treatment resistance in eating disorders is poorly understood, particularly concerning patients with multiple failed treatment attempts.
  • Existing criteria for severe and enduring anorexia nervosa often include multiple failed treatments, but the characteristics of these patients are unclear.
  • Differentiating patient profiles at initial admissions can inform prediction and characterization of inpatient treatment resistance.

Purpose of the Study:

  • To compare clinical and demographic characteristics of eating disorder patients with multiple, incomplete inpatient admissions versus those with good treatment outcomes.
  • To identify potential predictors of inpatient eating disorder treatment resistance at the time of initial admission.

Main Methods:

  • Analysis of existing data from a Canadian specialist inpatient eating disorder program (2000-2016).
  • Treatment resistance defined as ≥2 incomplete admissions and no complete admissions; good outcome defined as completed first admission and well at 1-year follow-up (BMI > 18.5, no binging/purging).
  • Statistical comparison using Mann-Whitney U tests, Chi-square tests, and logistic regression on variables including age, diagnoses, illness duration, psychopathology, behaviors, and depressive symptoms.

Main Results:

  • Patients with multiple incomplete admissions exhibited more severe eating disorder psychopathology and depressive symptoms at admission.
  • A higher prevalence of the binge purge subtype of anorexia nervosa was observed in the treatment-resistant group.
  • No significant differences were found in body mass index (BMI) or eating disorder behavior frequencies; a trend for longer illness duration was not statistically significant.

Conclusions:

  • Patients exhibiting treatment resistance in inpatient eating disorder care differ from those with good outcomes at initial admission.
  • Findings suggest treatment resistance may be a distinct concept from severe and enduring anorexia nervosa, warranting further research.
  • Early identification of specific clinical characteristics at admission could aid in predicting and managing treatment resistance.