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Updated: Nov 20, 2025

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
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LAG3's Enigmatic Mechanism of Action

Colin G Graydon1, Shifa Mohideen1, Keith R Fowke1,2,3,4

  • 1Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, MB, Canada.

Frontiers in Immunology
|January 25, 2021
PubMed

Keywords:
LAG3Lymphocyte activation gene-3checkpoint inhibitionimmune checkpointimmune checkpoint inhibitorsimmune exhaustionmechanism of action

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