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Engineered Aptamers for Enhanced COVID-19 Theranostics.

Caleb Acquah1, Jaison Jeevanandam2, Kei Xian Tan3

  • 1Faculty of Health Sciences, University of Ottawa, Ottawa, ON K1H 8M5 Canada.

Cellular and Molecular Bioengineering
|January 25, 2021
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Summary

Aptamers offer a promising solution for COVID-19 theranostics, enabling the development of rapid diagnostics and targeted therapeutics. Their specific binding characteristics make them ideal for combating SARS-CoV-2.

Keywords:
AptamersCOVID-19CoronavirusSARS-CoV-2Theranostics

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Area of Science:

  • Biomedical Engineering
  • Molecular Biology
  • Infectious Diseases

Background:

  • COVID-19, caused by SARS-CoV-2, presents a significant global health challenge.
  • SARS-CoV-2 enters host cells via clathrin-mediated endocytosis.
  • There is a critical need for rapid detection methods and targeted vaccines/therapeutics for COVID-19.

Purpose of the Study:

  • To systematically review and map the structural and functional characteristics of aptamers.
  • To explore the potential applications of aptamers in COVID-19 theranostics.

Main Methods:

  • Systematic literature review of PubMed, SCOPUS, Web of Science, and organizational reports.
  • Extensive discussion on aptameric systems for SARS-CoV-2 mitigation.

Main Results:

  • Aptamers exhibit high specificity and stability in target binding.
  • Aptamers can be engineered with relative ease for COVID-19 theranostic applications.
  • Progress in COVID-19 detection, drug repurposing, and vaccine development was discussed.

Conclusions:

  • Innovative biomedical technologies are urgently needed to address the impact of COVID-19.
  • Aptamer research shows potential for developing effective and affordable diagnostics, therapeutics, and vaccines for SARS-CoV-2 and other pathogens.