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Urate crystal deposition in hyperuricemic children: a dual energy computed tomography study

Qianqian Ying1, Jiapei Wang2, Yunyan Li2

  • 1Medicine School of Ningbo University, Ningbo, Zhejiang, China.

Archives of Medical Science : AMS
|January 25, 2021
PubMed

Insights

Dual energy CT (DECT) reveals urate crystal deposition in children with hyperuricemia (HUA). Symptomatic children show higher DECT urate deposits, particularly in the first MTP joint and calcaneus, highlighting the need for attention to pediatric HUA.

Area of Science:

  • Pediatric rheumatology
  • Medical imaging
  • Urology

Background:

  • Rising incidence of hyperuricemia (HUA) in children along China's coast.
  • Need to differentiate urate crystal deposition in symptomatic vs. asymptomatic pediatric HUA.

Purpose of the Study:

  • Compare DECT urate crystal deposition frequency in symptomatic vs. asymptomatic hyperuricemic children.
  • Identify common sites of urate deposition in pediatric HUA.

Main Methods:

  • Fifty-six hyperuricemic children divided into symptomatic (Joint Group, n=33) and asymptomatic (Asymptomatic Group, n=23).
  • Dual energy CT (DECT) scans of feet analyzed for urate crystal deposition.
  • Clinical features compared between groups.

Main Results:

  • DECT urate deposits found in 84.8% of symptomatic and 60.9% of asymptomatic children.
  • In symptomatic group, most frequent sites: first MTP joint (30.0%), ankle (15.0%), calcaneus (13.3%).
  • In asymptomatic group, most frequent sites: calcaneus (25.6%), first MTP joint (17.9%), first phalanx (15.4%).

Conclusions:

  • Urate deposition is present in children with HUA and more frequent in those with arthritis symptoms.
  • First MTP joint and calcaneus are common sites for urate deposition in pediatric HUA.
  • Increased attention to hyperuricemic children is warranted.
Abstract

Keywords:
childrendual-energy computed tomographyhyperuricemiajoint injuryurate crystal

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