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Author Spotlight: Studying the Impact of Maternal Dietary Deficiencies on Long-Term Offspring Health Outcomes
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Could high serum folate be associated with adverse effects?

Mahla Ghorbani1, Javad Baharara2, Mohammad Amin Kerachian3,4,5

  • 1Department of Biology, Faculty of Sciences, Mashhad Branch, Islamic Azad University, Mashhad, Iran.

Iranian Journal of Basic Medical Sciences
|January 25, 2021
PubMed
Summary

Folate is essential for preventing health issues like anemia and birth defects. However, high folic acid intake may pose risks, warranting further investigation into its long-term effects.

Keywords:
AgoutiEpigeneticFolic acidMTHFRMethylationPregnant

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Area of Science:

  • Nutrition Science
  • Biochemistry
  • Public Health

Background:

  • Folate is a vital water-soluble vitamin found in vegetables, fruits, and whole grains.
  • Folate deficiency is linked to megaloblastic anemia, cardiovascular disease, neural tube defects, and cancers.
  • The precise daily requirement for folate remains undetermined.

Purpose of the Study:

  • To explore the dual role of folate in health and disease.
  • To investigate concerns regarding folic acid supplementation.
  • To examine potential adverse effects of high folate intake.

Main Methods:

  • Literature review of existing studies on folate metabolism and health outcomes.
  • Analysis of research on folate deficiency and supplementation.
  • Examination of data on DNA methylation and gene expression related to folate intake.

Main Results:

  • Folate deficiency is associated with significant health complications.
  • Some studies raise concerns about folic acid supplementation potentially promoting tumor development and altering DNA methylation.
  • Clear evidence linking high folate intake to aberrant DNA methylation and gene expression is currently lacking.

Conclusions:

  • Folate is crucial for preventing serious health conditions.
  • The potential risks of high folic acid intake require careful consideration and further research.
  • Adverse effects of folate, particularly on fetal development and later life stages, warrant thorough investigation.