Related Experiment Video
Updated: Nov 20, 2025
08:16
High-Resolution Three-Dimensional Imaging of the Footpad Vasculature in a Murine Hindlimb Gangrene Model
Published on: March 16, 2022
3.8K
Terlipressin-induced foot ischemia
Fateen Ata1, Ahmed Mohamed Elmudathir Ahmed Osman1, Ines Dakhlia1
1Department of Internal Medicine Hamad Medical Corporation Doha Qatar.
Clinical Case Reports
|January 25, 2021
Summary
Terlipressin can rarely cause peripheral ischemia, a condition where blood flow to extremities is reduced. Prompt identification and treatment are crucial to prevent tissue death from this rare drug side effect.
Area of Science:
- Pharmacology
- Vascular Medicine
- Clinical Therapeutics
Background:
- Terlipressin is a vasopressor medication used for various conditions.
- Peripheral ischemia is a potential, though uncommon, adverse effect.
- Early recognition is key to managing this complication.
Purpose of the Study:
- To highlight the occurrence of terlipressin-induced peripheral ischemia.
- To emphasize the importance of timely diagnosis and intervention.
- To prevent irreversible tissue damage.
Main Methods:
- Review of clinical cases and literature.
- Analysis of patient data experiencing peripheral ischemia post-terlipressin administration.
- Case study approach.
Main Results:
- Terlipressin-induced peripheral ischemia is a rare but serious adverse event.
- Symptoms may include pain, pallor, and pulselessness in affected limbs.
- Delayed treatment can lead to necrosis.
Conclusions:
- Peripheral ischemia is a critical side effect of terlipressin.
- Vigilance for ischemic symptoms in patients receiving terlipressin is essential.
- Prompt management can avert permanent tissue damage and improve patient outcomes.
Related Concept Videos
01:21Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
166
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
166
01:27Peripheral Artery Disease III: Interprofessional Care
114
Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
114
01:26Peripheral Artery Disease IV: Nursing Management
157
The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses,...
157
01:26Cardiac Catheterization IV: Nursing Management
401
Nursing responsibilities before cardiac catheterization include:Assess for allergies and establish baseline health status.Before cardiac catheterization, assess the patient for allergies to contrast dye. Perform a comprehensive baseline assessment, including vital signs, heart and breath sounds, and a neurovascular assessment of the extremities, noting distal pulses, skin color, and temperature. Instruct the patient to fast for 8-12 hours before the procedure. Evaluate baseline laboratory...
401
01:26Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
667
The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
667
01:23Peripheral Artery Disease V: Postoperative Nursing Management
132
During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
132