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Related Experiment Video

Updated: Nov 20, 2025

FISH for Pre-implantation Genetic Diagnosis
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Published on: February 23, 2011

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Decision-making factors in prenatal testing: A systematic review.

Valentina Di Mattei1,2, Federica Ferrari2, Gaia Perego3

  • 1Vita-Salute San Raffaele University, Italy.

Health Psychology Open
|January 25, 2021
PubMed
Summary

Parental decisions about prenatal screening tests involve individual, contextual, and relational factors. Understanding these elements is crucial for informed choices regarding genetic testing for chromosomal abnormalities.

Keywords:
clinical health psychologygenetic testinghealth carepregnancysystematic review

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Area of Science:

  • Reproductive genetics
  • Medical decision-making
  • Psychology

Background:

  • Prenatal screening and diagnostic tests are vital for identifying chromosomal abnormalities.
  • Parental decision-making regarding these tests is complex and multifactorial.
  • Previous research has explored various influences on these choices.

Purpose of the Study:

  • To systematically review and synthesize factors influencing parental decision-making for prenatal screening and diagnostic tests.
  • To identify key individual, contextual, and relational elements impacting test evaluation.
  • To provide a comprehensive overview for healthcare providers and expectant parents.

Main Methods:

  • Systematic literature search conducted on PubMed and PsycInfo databases.
  • Inclusion criteria focused on studies investigating decision-making for prenatal testing of trisomy 21, 18, 13, and sex chromosome abnormalities.
  • Analysis of 46 English peer-reviewed studies.

Main Results:

  • Decision-making is influenced by individual factors (demographics, clinical history, psychological state).
  • Contextual factors, including test technicalities and information provided, play a significant role.
  • Relational aspects, involving family dynamics and societal influences, are also critical.

Conclusions:

  • The parental decision-making process for prenatal genetic testing is multifaceted.
  • Effective counseling should address individual, informational, and social contexts.
  • Further research can refine understanding of these complex choices for improved reproductive healthcare.