Related Experiment Video
Updated: Nov 20, 2025

An In vitro System to Gauge the Thrombolytic Efficacy of Histotripsy and a Lytic Drug
Published on: June 4, 2021
Single-Session Treatment of Upper Extremity Deep Venous Thrombosis and Central Venous Catheter Malfunction Using the
Siddharth Agarwal1, Christopher Sosnofsky2, Jamie Saum3
1Medicine, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, IND.
Insights
Upper extremity deep vein thrombosis (UEDVT) often occurs with central venous catheters (CVCs). Mechanical thrombectomy using the ClotTriever System successfully treated a patient with UEDVT and CVC malfunction, salvaging the catheter.
Area of Science:
- Vascular Medicine
- Interventional Radiology
Background:
- Upper extremity deep vein thrombosis (UEDVT) is frequently associated with central venous catheter (CVC) use, particularly in cancer patients.
- Existing treatment options for UEDVT lack consistent guidelines, necessitating individualized patient management.
- Potential sequelae of UEDVT include post-thrombotic syndrome and pulmonary embolism.
Observation:
- A case report details a 49-year-old female breast cancer patient presenting with UEDVT and CVC malfunction.
- The patient underwent successful mechanical thrombectomy to address the UEDVT.
- The ClotTriever System was utilized for the thrombectomy procedure.
Findings:
- Mechanical thrombectomy with the ClotTriever System effectively treated the UEDVT in this patient.
- The CVC was successfully salvaged during the same intervention session.
- This represents the first reported use of the ClotTriever System for UEDVT with simultaneous CVC salvage.
Implications:
- This case highlights the potential of mechanical thrombectomy with the ClotTriever System as a viable treatment for UEDVT.
- Simultaneous CVC salvage may offer a significant benefit to patients requiring long-term venous access.
- Further research may explore the broader application and efficacy of this approach in managing catheter-related UEDVT.
Abstract:
Intravenous catheters account for the majority of cases of upper extremity deep vein thrombosis (UEDVT), with a higher incidence in patients suffering from malignancy. Sequelae of UEDVT are similar to that of lower extremity DVT, comprising post-thrombotic syndrome and pulmonary embolism. While there are several treatment options for UEDVT including systemic anticoagulation, catheter-directed thrombolysis, and percutaneous mechanical thrombectomy, due to the absence of consistent guidelines regarding its management, treatment is often individualized based on patient characteristics, clinical factors, and technical considerations. We present a case of a 49-year-old female suffering from breast cancer with a central venous catheter (CVC) who came to the clinic with UEDVT and CVC malfunction and was successfully treated with mechanical thrombectomy using the ClotTriever System (Inari Medical, Irvine, CA). To our knowledge, this is the first report of the ClotTriever System being used to treat UEDVT and simultaneously salvage the CVC in a single session.
Related Concept Videos
Venous Thrombosis III: Interprofessional Care
Venous Thrombosis IV: Nursing Management
Venous Thrombosis I: Introduction
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care
Anticoagulant Drugs: Low-Molecular-Weight Heparins

