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Author Spotlight: Exploring the Antibacterial Effects of Zinc Oxide Nanoparticles in Overcoming Antibiotic Resistance
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Antibacterial and anticancer activity of ZnO with different morphologies: a comparative study
S C Esparza González1, Ena Bolaina-Lorenzo2, J J Pérez-Trujillo3
1School of Dentistry, Saltillo Campus, Autonomous University of Coahuila, Adolfo Lopez Mateos, 25125 Saltillo, Coahuila Mexico.
3 Biotech
|January 25, 2021
Summary
Spherical zinc oxide nanoparticles (ZnO NPS) exhibit potent antibacterial and anticancer properties. Their efficacy against E. coli, S. aureus, and HeLa cells surpasses other morphologies due to smaller particle size.
Area of Science:
- Materials Science
- Nanotechnology
- Biomedical Engineering
Background:
- Zinc oxide nanoparticles (ZnO NPS) are explored for their biological applications.
- Understanding the influence of nanoparticle morphology on bioactivity is crucial.
Purpose of the Study:
- To synthesize ZnO NPS with varying morphologies.
- To evaluate their antibacterial and anticancer activities.
- To correlate morphology with bioactivity.
Main Methods:
- Synthesis of spherical, hexagonal, and rod ZnO NPS.
- Physicochemical characterization using XRD, TEM, FTIR, and UV-Vis spectroscopy.
- In vitro testing against Escherichia coli, Staphylococcus aureus, and HeLa cancer cells.
Main Results:
- TEM confirmed spherical (20 nm), hexagonal, and rod ZnO NPS.
- XRD indicated crystalline ZnO in the wurtzite phase.
- Biological assays demonstrated dose-dependent reduction in bacterial and cancer cell viability.
- Spherical ZnO NPS showed superior antibacterial and anticancer activity at 100 µg/mL.
Conclusions:
- ZnO NPS exhibit significant antibacterial and anticancer potential.
- Spherical ZnO NPS demonstrate enhanced efficacy compared to hexagonal and rod forms.
- Particle size is a key factor influencing the bioactivity of ZnO NPS.
