CircRNAs: Emerging Bladder Cancer Biomarkers and Targets
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Published on: January 5, 2017
Zhaofeng Liang1, Wenhao Guo1, Shikun Fang1
1Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, China.
Abstract:
Circular RNAs (circRNAs) are newly discovered intriguing RNAs due to the covalently closed loop structure, high stability, tissue specificity, and functional diversity. In recent years, a large number of circRNAs have been identified through high-throughput sequencing technology and bioinformatics methods, the abnormal expression of circRNAs are closely related to many diseases including bladder cancer (BC). CircRNAs have been proven to have several functions, such as acting as a regulator of parental gene transcription, miRNA sponge and interacting with proteins to regulate its expression. In addition, some circRNAs have been identified to encode proteins. CircRNAs have the characteristics of high abundance, high stability, wide distribution in body fluids, tissue specificity, and developmental stage specificity, which determine that circRNAs has great potential to be utilized as biomarkers for BC. Herein, we briefly summarize the biogenesis, functions and roles, and the current research progress of circRNAs in BC with a focus on the potential application for BC diagnosis, treatment, and prognosis.
Insights
Circular RNAs (circRNAs) show promise as biomarkers for bladder cancer (BC) due to their stability and specific expression. Research highlights their roles in BC development and potential for diagnosis and treatment.
Area of Science:
- Molecular Biology
- Genomics
- Oncology
Background:
- Circular RNAs (circRNAs) are covalently closed RNA molecules with unique stability and diverse functions.
- Aberrant expression of circRNAs is linked to various diseases, including bladder cancer (BC).
Purpose of the Study:
- To summarize the biogenesis, functions, and roles of circRNAs in bladder cancer.
- To review the current research progress on circRNAs in BC.
- To focus on the potential application of circRNAs as biomarkers for BC diagnosis, treatment, and prognosis.
Main Methods:
- High-throughput sequencing technology
- Bioinformatics analysis
- Literature review
Main Results:
- CircRNAs possess characteristics like high abundance, stability, and tissue specificity, making them suitable biomarkers.
- CircRNAs function as regulators of gene transcription, miRNA sponges, and protein interactors.
- Some circRNAs have been identified to encode proteins.
Conclusions:
- CircRNAs hold significant potential as diagnostic, therapeutic, and prognostic biomarkers for bladder cancer.
- Further research into circRNAs could lead to novel strategies for BC management.
